Prevention and Treatment of Cytarabine-Induced …
Corneal toxicity with high-dose cytarabine is a well-established risk of therapy. Routine prophylaxis with eye drops, usually topical corticosteroid drops, is an established part of high-dose cytarabine treatment protocols.
Cytarabine-Induced Corneal Toxicity: Clinical Features and …
We report two patients who developed toxic keratopathy following high-dose cytarabine chemotherapy and whose symptoms resolved following topical loteprednol etabonate 0.5% treatment. A 25-year-old woman and a 26-year-old man with acute myeloid ...
Ocular toxicities associated with high dose cytarabine
High dose cytarabine has been associated with ocular toxicities in up to 85% of patients in the absence of corticosteroid eye drops. Topical corticosteroid eye drops have been reported to reduce the incidence of clinically significant kerato-conjunctivitis to about 8-16%. r
EyeRounds.org: Cytarabine-induced Keratoconjunctivitis
2023年1月26日 · Cytarabine-induced keratoconjunctivitis is generally self-limited with reversible corneal damage. Symptoms generally resolve within a week of therapy initiation. However, intraepithelial microcysts may be seen up to 4 weeks post-treatment.[2]
Ocular side effects of systemically administered chemotherapy
2024年8月27日 · Herpes simplex keratitis; Initial systemic therapy for metastatic esophageal and gastric cancer; Major adverse effects of low-dose methotrexate; Management of recurrent or metastatic cervical cancer; Nonarteritic anterior ischemic optic neuropathy: Clinical features and …
Early-stage corneal toxicity secondary to high-dose systemic cytarabine …
2023年3月6日 · High-dose systemic cytarabine chemotherapy may cause fine corneal opacities and refractile microcysts, which are densely distributed in the center of the cornea.
Corneal toxicity with systemic cytarabine - PubMed
The corneal changes we observed with high doses of systemic cytarabine resembled descriptions of corneal toxicity from topical cytarabine and were probably secondary to inhibition of DNA synthesis in the corneal epithelium.
Cytarabine-induced corneal toxicity | Eye - Nature
2003年7月10日 · Although uncommon, this case confirms that cytarabine corneal toxicity can occur with low-dose regimens and it is recommended that all patients receiving cytarabine therapy should receive ...
Cytarabine Side Effects: Common, Severe, Long Term - Drugs.com
2024年7月8日 · Applies to cytarabine: injectable powder for injection, injectable solution. Ocular adverse events Very common (10% or more): Hemorrhagic conjunctivitis , corneal disorder
Keratitis from high doses intravenous cytarabine - PubMed
1982年7月31日 · Cytarabine / administration & dosage Cytarabine / adverse effects* Humans Injections, Intravenous Keratitis / chemically induced*
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