Insights about clinically approved and Preclinically investigated ...
2020年11月1日 · Cytarabine is an artificial analogue of NPs termed spongothymidine and spongouridine, obtained from the marine sponge Tectitethya crypta (Jimenez et al., 2018). It is known as cytosine arabinoside (Ara C), for the management of diverse leukemia types and non-Hodgkin's lymphoma (Indumathy and Dass, 2013).
Marine Compounds and Cancer: The First Two Decades of XXI …
In 2019, the scientific and medical community celebrated the 50th anniversary of the introduction of the very first marine-derived drug, Cytarabine, into clinics. Cytarabine (aka Ara-C, Cytosar-U ®) was first isolated from a marine sponge and is known to kill cancer cells by blocking DNA polymerase function . In 1969, the FDA approved the drug ...
From Life in the Sea to the Clinic: The Marine Drugs Approved and …
Cytarabine (cytosine arabinoside or arabinosyl cytosine, ara-C) is a pyrimidine arabinoside nucleoside developed starting from spongothymidine or Ara-T. Produced synthetically in 1959 and patented in 1960, cytarabine entered the market in the USA in 1969 under the trade name Cytosar-U ® (Upjhon, Kalamazoo, MI, USA).
Marine Sponges as a Drug Treasure - PMC - PubMed Central (PMC)
Marine sponges have been considered as a drug treasure house with respect to great potential regarding their secondary metabolites. Most of the studies have been conducted on sponge’s derived compounds to examine its pharmacological properties.
Marine organisms as a source of new anticancer agents
The isolation of C-nucleosides from the Caribbean sponge, Cryptotheca crypta, four decades ago, provided the basis for the synthesis of cytarabine, the first marine-derived anticancer agent to be developed for clinical use.
Marine Compounds and Cancer: The First Two Decades of XXI …
2019年12月26日 · In 2019, the scientific and medical community celebrated the 50th anniversary of the introduction of the very first marine-derived drug, Cytarabine, into clinics. Cytarabine (aka Ara-C, Cytosar-U ®) was first isolated from a marine sponge and is known to kill cancer cells by blocking DNA polymerase function . In 1969, the FDA approved the drug ...
Chemical structures of cytarabine and related natural products ...
Cytarabine (1) is a synthetic pyrimidine nucleoside containing a cytosine base derived from a specific program based on the natural marine products spongothymidine (2) and spongouridine (3),...
Radiosensitization by Marine Sponge Agelas sp. Extracts in ...
2018年4月20日 · We selected six methanol extracts of marine sponges collected from the Micronesian ocean and identified marine-derived bioactivity with potential application for radiation therapy. We measured the...
An Overview on Marine Sponge-Symbiotic Bacteria as Unexhausted …
2017年9月21日 · A large number of highly active anti-cancer compounds have been isolated from marine invertebrates, including eleutherobin (Eleutherobia corals), sarcodictyin (Stolonigeran coral) , cytarabine (sponge-Tectitethya crypta) , and …
Marine-derived drugs: Recent advances in cancer therapy and …
2021年2月1日 · United States (US) Food and Drug Administration (FDA) has approved some of the essential anticancer drugs that are obtained from marine sources, including cytarabine (also known as Cytosar U®) is a chemotherapeutic drug used for the therapy of malignant acute myeloid, lymphoytic and myelogenous leukemia, and non-Hodgkin's lymphoma (nHL).