D-amino acid oxidase - Wikipedia
D-amino acid oxidase (DAAO; also OXDA or DAMOX) is an enzyme with the function on a molecular level to oxidize D-amino acids to the corresponding α-keto acids, producing ammonia and hydrogen peroxide. This results in a number of physiological effects in various systems, most notably the brain.
Human D-Amino Acid Oxidase: Structure, Function, and Regulation
2018年11月28日 · D-Amino acid oxidase (DAAO) is an FAD-containing flavoenzyme that catalyzes with absolute stereoselectivity the oxidative deamination of all natural D-amino acids, the only exception being the acidic ones. This flavoenzyme plays different roles during evolution and in different tissues in humans.
D-Amino Acid Oxidase - an overview | ScienceDirect Topics
D-amino acid oxidase (EC 1.4.3.3, DAAO) is a flavoenzyme that catalyzes the oxidative deamination of D-amino acids to give the corresponding α-keto acids and ammonia.
Biochemical Properties of Human D-Amino Acid Oxidase - PMC
D-amino acid oxidase (DAAO, EC 1.4.3.3) is the FAD-containing enzyme that catalyzes the strictly stereospecific oxidative deamination of the D-isomer of neutral amino acids. Since its discovery in pig kidney (Krebs, 1935 ), DAAO has been widely studied as a prototype of FAD-dependent oxidases (Mattevi et al., 1996 ; Pilone, 2000 ).
D-amino acid oxidase: physiological role and applications
D-Amino acids play a key role in regulation of many processes in living cells. FAD-dependent D-amino acid oxidase (DAAO) is one of the most important enzymes responsible for maintenance proper level of D-amino acids.
D-amino acid oxidase: structure, catalytic mechanism, and …
D-Amino acid oxidase (DAAO) is a FAD-dependent enzyme that plays an important role in microbial metabolism, utilization of endogenous D-amino acids, regulation of the nervous system, and aging in mammals.
Biochemical Properties of Human D-amino Acid Oxidase Variants …
The stereoselective flavoenzyme D-amino acid oxidase (DAAO) catalyzes the oxidative deamination of neutral and polar D-amino acids producing the corresponding α-keto acids, ammonia, and hydrogen peroxide.
Human D-amino acid oxidase: an update and review - PubMed
2015年3月18日 · The flavoprotein D-amino acid oxidase (DAO) degrades the gliotransmitter D-Ser, a potent activator of N-methyl-D-aspartate-type glutamate receptors. A body of evidence suggests that DAO, together with its activator, G72 protein, may play a key role in the pathophysiology of schizophrenia.
D-Amino acid oxidase: new findings - PMC - National Center for ...
The most recent research on D-amino acid oxidases and D-amino acid metabolism has revealed new, intriguing properties of flavoenzymes and enlighted novel biotechnological uses of this catalyst.
D-Amino Acid Oxidase - an overview | ScienceDirect Topics
D-Amino Acid Oxidase (DAAO) is an enzyme that oxidizes D-amino acids, showing a preference for proline, methionine, and alanine. It plays a role in NMDA receptor signaling as demonstrated by its impact on reducing NMDA functioning in brain and retina tissues.