Polymeric DNA hydrogel: Design, synthesis and applications
2019年11月1日 · This review highlights recent progress on DNA hydrogels from a polymeric perspective, including general molecular design principles, synthesis strategies, and applications. DNA hydrogels are categorized according to the structure of building blocks including linear DNA, dendritic DNA and hybrid.
Biomedical Applications of DNA-Based Hydrogels - Wiley …
DNA hydrogels are an emerging class of soft materials with great potential in biomedical applications. DNA offers unprecedented levels of programmability, enabling precise assembly of its constituent...
Functional DNA Based Hydrogels: Development, Properties and …
DNA-based hydrogels significantly attracted attention in recent years owing to their properties and applications in biosensing, bioimaging, and therapeutics. Here, we summarize the recent advances in the area of DNA hydrogels where these are used either as structural material or as functional entities to make hybrid constructs with various ...
DNA hydrogels: Principles, synthesis, characterization and …
2022年1月1日 · DNA Hydrogels show biodegradability, biocompatibility, modularity, non-toxicity, hydrophilicity, self-healing ability, and the ability to probe, program, and reprogram diverse biological systems. This chapter focuses on pure DNA-based hydrogels, their principles, and synthesis methods.
Enzyme-catalysed assembly of DNA hydrogel | Nature Materials
2006年9月24日 · Here we report the construction of a hydrogel entirely from branched DNA that are three-dimensional and can be crosslinked in nature. These DNA hydrogels were biocompatible, biodegradable,...
DNA hydrogel-based gene editing and drug delivery systems
2021年1月1日 · We conduct this review in three steps, first summarizing the basic design and synthesis principles of DNA hydrogels, then introducing the stimuli responsiveness of smart DNA hydrogels, and finally highlighting DNA hydrogel-based drug delivery platforms, to include the delivery of biomacromolecules in immunotherapy, gene therapy and combination ...
Rolling circle amplification (RCA)-based DNA hydrogel - Nature
2021年10月29日 · Here, we describe a rolling circle amplification (RCA)-based synthesis of 3D DNA hydrogels with rationally programmed sequences and tunable physical, chemical and biological properties.
Recent Advances in Stimuli-Responsive DNA-Based Hydrogels
2022年2月9日 · This review highlights recent advances in the design of responsive pure DNA hydrogels, DNA–polymer hybrid hydrogels, and autonomous DNA-based hydrogels with transient behaviors.
A DNA-based hydrogel for exosome separation and biomedical ... - PNAS
Herein, we report a DNA-based hydrogel to realize the specific and nondestructive separation of EXOs from complex biological media. The DNA hydrogel was constructed from ultralong single-stranded DNA (ssDNA) that was synthesized via double-rolling circle amplification (RCA) (20, 21).An aptamer that specifically recognized tetraspanin CD63 on EXOs (22–24), named AptCD63, was designed in the ...
DNA hydrogels and their derivatives in biomedical engineering ...
2024年8月29日 · DNA hydrogels are polymer networks comprising cross-linked DNA strands. As DNA hydrogels present programmability, biocompatibility, and stimulus responsiveness, they are extensively explored in the field of biomedicine. In this study, we provide an overview of recent advancements in DNA hydrogel technology.