Dihydrofolic acid - Wikipedia
Dihydrofolic acid (conjugate base dihydrofolate) (DHF) is a folic acid (vitamin B 9) derivative which is converted to tetrahydrofolic acid by dihydrofolate reductase. [1] Since tetrahydrofolate is needed to make both purines and pyrimidines , which are building blocks of DNA and RNA , dihydrofolate reductase is targeted by various drugs to ...
Dihydrofolate reductase - Wikipedia
Dihydrofolate reductase, or DHFR, is an enzyme that reduces dihydrofolic acid to tetrahydrofolic acid, using NADPH as an electron donor, which can be converted to the kinds of tetrahydrofolate cofactors used in one-carbon transfer chemistry.
二氢叶酸 - 维基百科，自由的百科全书
二氢叶酸（英語： Dihydrofolic acid ）是一个叶酸衍生物，被二氢叶酸还原酶作用后会生成四氢叶酸。 因为动植物需要四氢叶酸制造嘌呤与嘧啶，故许多药物的靶点都指向二氢叶酸还原酶以阻止核酸的合成。 二氢叶酸也可被叫做二氢叶酸盐，更常用的名称是维生素B 9
Dihydrofolic acid | C19H21N7O6 | CID 135398604 - PubChem
Dihydrofolic acid is a folic acid derivative acted upon by dihydrofolate reductase to produce tetrahydrofolic acid. It interacts with bacteria during cell division and is targeted by various drugs to prevent nucleic acid synthesis.
Dihydrofolate Reductase - an overview | ScienceDirect Topics
Dihydrofolate reductase is an enzyme that is present in all mammalian cells and is responsible for the reduction of dihydrofolate to tetrahydrofolate. Tetrahydrofolate is essential for the synthesis of tetrahydrofolate cofactors, which are important for various biosynthetic pathways involved in the production of purines, amino acids, and thymidine.
Dihydrofolate Reductase Gene Variations in Susceptibility to …
Dihydrofolate reductase (DHFR) catalyzes the reduction of dihydrofolate to tetrahydrofolate (THF). THF is needed for the action of folate-dependent enzymes and is thus essential for DNA synthesis and methylation. The importance of this reaction is ...
二氢叶酸还原酶 - 百度百科
二氢叶酸还原酶（dihydrofolate reductase，DHFR）是利用NADPH还原二氢叶酸产生四氢叶酸的氧化还原酶。
二氢叶酸 - 百度百科
二氢叶酸是指生物的叶酸辅酶（四氢叶酸）生物合成的中间体。其本身不具辅酶活性。
二氢叶酸还原酶 - 维基百科，自由的百科全书
二氢叶酸还原酶 [1] （英語： Dihydrofolate reductase ，简称为DHFR）是一种将二氢叶酸还原为四氢叶酸的酶，并以NADPH作为电子供体，后者可被转换为多种四氢叶酸辅酶被用于化学上的一碳单位转移。
7,8-Dihydrofolate | C19H19N7O6-2 | CID 135398603 - PubChem
Dihydrofolate(2-) is dianion of dihydrofolic acid arising from deprotonation of both carboxylic acid functions. It has a role as a human metabolite and a Saccharomyces cerevisiae metabolite. It is a dicarboxylic acid dianion and a member of dihydrofolates.