Disulfide - Wikipedia
The structure of a disulfide bond can be described by its χ ss dihedral angle between the C β −S γ −S γ −C β atoms, which is usually close to ±90°. The disulfide bond stabilizes the folded form of a protein in several ways: It holds two portions of the protein together, biasing the protein towards the folded topology.
二硫键 - 百度百科
二硫键（disulfide bond） 是连接不同肽链或同一肽链中两个半胱氨酸的化学键。 二硫键是比较稳定的共价键，在蛋白质分子中，起着稳定肽链空间结构的作用。
Disulfide Bond - an overview | ScienceDirect Topics
A disulfide bond is a post-translational modification that covalently links the sulfur atoms of two cysteine residues in close spatial proximity so that proteins are internally or externally cross-linked. From: Computational and Structural Biotechnology Journal, 2020
Disulfide Bonds in Protein Folding and Stability
2018年7月27日 · In this chapter, we review the biophysical properties of disulfide bonds and how they affect the structure and folding of individual proteins. Based on this, we discuss similarities and differences between in vitro and in vivo folding reactions.
Structural Biochemistry/Chemical Bonding/ Disulfide bonds
2020年1月26日 · A disulfide bond, also called an S-S bond, or disulfide bridge, is a covalent bond derived from two thiol groups. In biochemistry, the terminology R-S-S-R connectivity is commonly used to describe the overall linkages.
From structure to redox: the diverse functional roles of disulfides …
Disulfide bonds are essential to the structural stability of many proteins within the secretory pathway and can exist as intramolecular or inter-domain disulfides. The proper formation of these bonds often relies on folding chaperones and oxidases such as members of the protein disulfide isomerase (PDI) family.
Reactivity of disulfide bonds is markedly affected by ... - Nature
2016年12月12日 · Disulfide bonds play a key role in stabilizing protein structures, with disruption strongly associated with loss of protein function and activity. Previous data have suggested that disulfides...
Disulfide bond - UniProt
In UniProtKB, we annotate intrachain and interchain disulfide bonds and redox-active centres. We annotate both experimentally determined disulfide bonds and predicted disulfide bonds which occur in specific protein families.
Prediction of disulfide bond engineering sites using a machine …
2020年6月25日 · A disulfide bond prediction algorithm that aims to improve crystal quality has been developed to locate the potential disulfide bonds that lead to lower entropy of the protein...
Disulfide Bond - an overview | ScienceDirect Topics
Disulfide bonds are highly stabilizing covalent interactions between the sulfhydryl groups of neighboring cysteinyl residues. Due to the strength of the –S—S– bond, these interactions provide extreme stabilization against denaturation.