MAPK/ERK pathway - Wikipedia
The MAPK/ERK pathway (also known as the Ras-Raf-MEK-ERK pathway) is a chain of proteins in the cell that communicates a signal from a receptor on the surface of the cell to the DNA in the nucleus of the cell.
ERK signalling: a master regulator of cell behaviour, life and fate
2020年6月23日 · ERK-activated kinases of the ribosomal protein S6 kinase (RSK), mitogen- and stress-activated protein kinase (MSK) and MAPK-interacting kinase (MNK) families significantly expand the repertoire...
MAPK/ERK信号通路图及简介-丁香实验 - biomart.cn
2013年8月27日 · MAPK,丝裂原活化蛋白激酶(mitogen-activated protein kinases，MAPKs)是细胞内的一类丝氨酸/苏氨酸蛋白激酶。 研究证实，MAPKs信号转导通路 存在于大多数细胞内，在将细胞外刺激信号转导至细胞及其核内，并引起细胞生物学反应(如细胞增殖、分化、转化及凋亡等)的 …
MAPK信号通路：Ras/Raf/MEK/ERK途径与肿瘤关系 - 每日生物评论
2021年7月21日 · 丝裂原活化蛋白激酶MAPK信号途径是细胞中大佬级别的信息传递链，由细胞内广泛表达的Ser/Thr蛋白激酶，参与细胞的生长、发育、分化、凋亡等一系列细胞生理活动，是诱发肿瘤产生的重灾区。 目前，虽然研究MAPK信号传导与肿瘤之间关系取得了不错的进展，但要完全揭示其机制，还需要更加深入的研究。 已知的 MAPK信号通路 有四类，今天我们主要介绍其中Ras/Raf/MEK/ERK途径与肿瘤千丝万缕的关系。 熟悉信号通路的童鞋们肯定知道Ras、Raf …
ERK/MAPK signalling pathway and tumorigenesis - PubMed
The Ras/Raf/MAPK (MEK)/ERK pathway is the most important signalling cascade among all MAPK signal transduction pathways, and plays a crucial role in the survival and development of tumour cells. The present review discusses recent studies on Ras and ERK pathway members.
生长和分化中的 MAPK/Erk - Cell Signaling Technology (CST)
MAPK/Erk 信号级联放大通过生长和分化中涉及的各种不同受体进行激活，包括受体酪氨酸激酶 (RTKs)、整合素以及离子通道。 由不同的刺激物激活的级联反应的特定组分差异较大，但通路的结构通常包含一组对接蛋白（Shc、GRB2、Crk 等），它们将受体连接到一个鸟苷酸交换因子上（SOS、C3G 等），信号则转导至小分子 GTP 结合蛋白 (Ras，Rap1)，后者再激活级联中的核心单位，包括一个 MAPKKK (Raf)、一个 MAPKK (MEK1/2) 和 MAPK (Erk)。 激活的 Erk 二聚 …
MAPK signal pathways in the regulation of cell proliferation in ...
2002年3月1日 · Mitogen-activated protein kinase (MAPK) cascades have been shown to play a key role in transduction extracellular signals to cellular responses. In mammalian cells,...
Signaling pathway of MAPK/ERK in cell proliferation ... - PubMed
Mitogen-activated protein kinases/extracellular signal-regulated kinase (MAPK/ERK) pathway is reported to be associated with the cell proliferation, differentiation, migration, senescence and apoptosis.
ERK1/2 MAP kinases: Structure, function, and regulation
2012年8月1日 · ERK1/2 are proline-directed kinases that preferentially catalyze the phosphorylation of substrates containing a Pro-Xxx-Ser/Thr-Pro sequence. Besides this primary structure requirement, many ERK1/2 substrates possess a …
Targeting the RAS/RAF/MAPK pathway for cancer therapy: from
2023年12月18日 · RAF kinase is a primary mediator of the MAPK pathway, responsible for the sequential activation of downstream targets, such as MEK and the transcription factor ERK, which...
- 某些结果已被删除