Fibroblast growth factor receptor 1 - Wikipedia
FGFR1, when bound to a proper FGF, elicits cellular responses by activating signaling pathways that include the: a) Phospholipase C/PI3K/AKT, b) Ras subfamily/ERK, c) Protein kinase C, d) …
Pharmacological and Biological Targeting of FGFR1 in Cancer
2024年11月18日 · This review will outline the structural features of FGFR1 and its signaling pathways, delineate the roles of different FGFR1 mutation types in tumorigenesis, and discuss …
understanding of FGF signaling and its roles in organ development, injury repair, and the pathophysiology of spectrum of diseases, which is a consequence of FGF signaling …
Targeting FGFR for cancer therapy - Journal of Hematology
2024年6月3日 · The FGFR signaling pathway is integral to cellular activities, including proliferation, differentiation, and survival. Dysregulation of this pathway is implicated in …
N-glycosylation acts as a switch for FGFR1 trafficking between the ...
2023年7月21日 · Fibroblast growth factor receptor 1 (FGFR1) is a heavily N-glycosylated cell surface receptor tyrosine kinase that transmits signals across the plasma membrane, in …
Differential regulation of fibroblast growth factor receptor 1 ...
2019年6月17日 · To study the impact of galectins on FGFR1 function we analyzed activation of FGFR1 and receptor-dependent signaling pathways using mouse NIH3T3 fibroblasts, which …
Molecular Pathways: Fibroblast Growth Factor Signaling: A New ...
2012年4月1日 · Fibroblast growth factors (FGF) and their receptors (FGFR) tightly regulate key cell behaviors, such as proliferation, differentiation, migration, and survival, and are …
FGF Signaling Pathway: A Key Regulator of Stem Cell Pluripotency
2020年2月17日 · The FGF ligands elicit their activity by using four transmembrane tyrosine kinase receptors FGFR1, FGFR2, FGFR3, and FGFR4 (Hui et al., 2018). The activated FGFRs will …
The diverse dependence of galectin-1 and -8 on multivalency for …
2024年5月15日 · FGFR1 signaling ensures homeostasis of cells by fine-tuning essential cellular processes, like differentiation, division, motility and death. FGFR1 activity is coordinated at …
Fibroblast Growth Factor Receptors (FGFRs) and Noncanonical
2021年5月14日 · Canonical FGF-FGFR signaling is tightly regulated by ligand-receptor combinations as well as direct interactions with the FGFR coreceptors heparan sulfate …