Fetal hemoglobin in sickle cell anemia - PMC - PubMed Central …
Fetal hemoglobin (HbF) can blunt the pathophysiology, temper the clinical course, and offer prospects for curative therapy of sickle cell disease. This review focuses on (1) HbF quantitative trait loci and the geography of β-globin gene haplotypes, ...
Fetal hemoglobin in sickle cell anemia | Blood | American …
2020年11月19日 · Fetal hemoglobin (HbF) can blunt the pathophysiology, temper the clinical course, and offer prospects for curative therapy of sickle cell disease.
Induction of Fetal Hemoglobin in the Treatment of Sickle Cell Disease
2006年1月1日 · Reactivation of fetal hemoglobin (HbF) expression is an important therapeutic option in patients with hemoglobin disorders. In sickle cell disease (SCD), an increase in HbF inhibits the polymerization of sickle hemoglobin and the resulting pathophysiology.
Fetal haemoglobin induction in sickle cell disease - PMC
Fetal haemoglobin (HbF, α2γ2) induction has long been an area of investigation, as it is known to ameliorate the clinical complications of sickle cell disease (SCD). Progress in identifying novel HbF-inducing strategies has been stymied by limited understanding of …
CRISPR-Cas9 to induce fetal hemoglobin for the treatment of sickle cell …
2021年12月10日 · Given the ability of fetal hemoglobin (HbF) to inhibit sickle hemoglobin polymerization, HbF reactivation by the creation of naturally occurring HbF-associated mutations, editing HbF repressors/their binding site, or epigenetic intermediates using …
Fetal haemoglobin in sickle-cell disease: from genetic ... - PubMed
2016年6月18日 · Induction of fetal haemoglobin production is a promising strategy for the treatment of sickle-cell disease. In this Series paper, we review scientific breakthroughs in epidemiology, genetics, and molecular biology that have brought reactivation of fetal haemoglobin to the forefront of sickle-cell disease research.
CRISPR-Cas9 to induce fetal hemoglobin for the treatment of sickle cell …
2021年10月1日 · Fetal hemoglobin (HbF) inhibits sickle hemoglobin (HbS) polymerization, and it is well described that naturally occurring hereditary persistence of HbF (HPFH) alleviates disease symptoms; therefore, reawakening of developmentally silenced HbF in adult red blood cells (RBCs) has long been of interest as a therapeutic strategy.
Fetal haemoglobin in sickle-cell disease: from genetic epidemiology …
2016年6月18日 · Induction of fetal haemoglobin production is a promising strategy for the treatment of sickle-cell disease. In this Series paper, we review scientific breakthroughs in epidemiology, genetics, and molecular biology that have brought reactivation of fetal haemoglobin to the forefront of sickle-cell disease research.
Fetal hemoglobin (HbF) inhibits sickle hemo-globin (HbS) polymerization, and it is well described that natu-rally occurring hereditary persistence of HbF (HPFH) alleviates disease symptoms; therefore, reawakening of developmentally silenced HbF in adult red blood cells (RBCs) has long been of interest as a therapeutic strategy.
Fetal haemoglobin in sickle-cell disease: from genetic epidemiology …
2016年6月18日 · Induction of fetal haemoglobin production is a promising strategy for the treatment of sickle-cell disease. In this Series paper, we review scientific breakthroughs in epidemiology, genetics, and molecular biology that have brought reactivation of fetal haemoglobin to the forefront of sickle-cell disease research.
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