How the Respiratory Epithelium Senses and Reacts to Influenza Virus
2018年8月2日 · The bias toward type III IFN responses is restricted to tissues continually exposed to pathogens, such as the lungs and gut.
How Flu Damages Lung Tissue - ScienceDaily
2009年7月20日 · The researchers report that M2, a protein in the flu virus, damages a protein responsible for clearing fluid from the lungs by increasing the amount of oxidants, or free radicals, within the...
Influenza A Virus Cell Entry, Replication, Virion Assembly and …
While the bulk of the vRNP trafficking work has been carried out using various immortalized cell lines, the potential species related differences, and the essential role of vRNP trafficking in reassortment, emphasize the need for further methodology development to examine the details of IAV entry in primary cells and tissue explants.
The induction and consequences of Influenza A virus-induced cell …
2018年9月25日 · Rodrigue-Gervais, I. G. et al. Cellular inhibitor of apoptosis protein cIAP2 protects against pulmonary tissue necrosis during influenza virus infection to promote host survival.
Linking Influenza Virus Tissue Tropism to Population-Level
2012年8月28日 · Influenza virus tissue tropism defines the host cells and tissues that support viral replication and contributes to determining which regions of the respiratory tract are infected in humans.
From virus to inflammation, how influenza promotes lung damage
Therefore, developing an effective therapeutic regimen against influenza requires a comprehensive understanding of the damage-associated immune-mechanisms to identify therapeutic targets for interventions to mitigate inflammation/tissue-damage, improve antiviral immunity, and prevent influenza-associated secondary bacterial diseases.
Viral Tropism and the Pathogenesis of Influenza in the Mammalian …
Examination of additional tissue from naturally occurring disease would greatly help clarify the role of viral tropism and other virulence factors in disease progression.
Tropism, replication competence, and innate immune responses of ...
2018年7月9日 · The aim of this study was to compare replication competence, tissue tropism, and host responses elicited by human and avian strains of influenza A virus in ex-vivo human bronchus and human airway organoids.
Single-cycle influenza virus vaccine generates lung CD8
2023年9月8日 · S-FLU vaccination is non-inflammatory, causes minimal lung tissue damage, and generates a clonally diverse cross-reactive lung CD8 + memory T cell pool that can protect against severe disease without driving the virus to rapidly evolve and escape.
Linking influenza virus tissue tropism to population-level
Influenza virus tissue tropism defines the host cells and tissues that support viral replication and contributes to determining which regions of the respiratory tract are infected in humans.