Heme and FLVCR-related transporter families SLC48 and SLC49
Feline leukemia virus subgroup C receptor (FLVCR1), a member of the SLC49 family of four paralogous genes, is a cell surface heme exporter, essential for erythropoiesis and systemic iron homeostasis. Disruption of FLVCR1 function blocks development of erythroid progenitors, likely due to heme toxicity.
Heme and FLVCR-related transporter families SLC48 and SLC49
Feline leukemia virus subgroup C receptor (FLVCR1), a member of the SLC49 family of 4 paralogous genes, is a cell surface heme exporter, essential for erythropoiesis and systemic iron homeostasis. Disruption of FLVCR1 function blocks development of erythroid progenitors, likely due to heme toxicity.
Export of heme by the feline leukemia virus C receptor regulates ...
2024年5月31日 · Here, we found that RpFLVCR is a heme exporter in the midgut of the hematophagous insect Rhodnius prolixus, a vector for Chagas disease. Silencing RpFLVCR decreased hemolymphatic heme levels and increased the levels of intracellular dicysteinyl-biliverdin, indicating heme retention inside midgut cells.
Control of intracellular heme levels: Heme transporters and heme ...
2011年5月1日 · Here we review aspects of heme metabolism and discuss our current understanding of heme transporters, with emphasis on the function of the cell-surface heme exporter, FLVCR. Knockdown of Flvcr in mice leads to both defective erythropoiesis and disturbed systemic iron homeostasis, underscoring the critical role of heme transporters in mammalian ...
Heme exporter FLVCR is required for T cell development and …
2015年2月2日 · Here we show that deletion of Flvcr in murine hematopoietic precursors caused a complete block in αβ T cell development at the CD4+CD8+ double-positive stage, though other lymphoid lineages were unaffected. Moreover, FLVCR was required for the proliferation and survival of peripheral CD4+ and CD8+ T cells.
FLVCR, a Heme Exporter, Is Required for Peripheral T Cell …
2012年11月16日 · The feline leukemia virus subgroup C receptor (FLVCR) exports heme from cells. Conditional deletion of Flvcr was shown to cause progressive anemia in neonatal and adult mice (Science 319:825–8, 2008).
A Heme Export Protein Is Required for Red Blood Cell ... - Science
2008年2月8日 · Mice with FLVCR that is deleted neonatally develop a severe macrocytic anemia with proerythroblast maturation arrest, which suggests that erythroid precursors export excess heme to ensure survival. We further demonstrate that FLVCR mediates heme export from macrophages that ingest senescent red cells and regulates hepatic iron.
Heme exporter FLVCR is required for T cell development and
2015年2月15日 · The feline leukemia virus subgroup C receptor (FLVCR) is a 12-transmembrane domain surface protein that exports heme from cells, and it was shown to be required for erythroid development. In this article, we show that deletion of Flvcr in murine hematopoietic precursors caused a complete block in αβ T cell development at the CD4(+)CD8 ...
Heme Exporter FLVCR1a Regulates Heme Synthesis and …
2014年5月1日 · Feline leukemia virus subgroup C cellular receptor 1a (FLVCR1a) is plasma membrane heme exporter that is ubiquitously expressed and controls intracellular heme content in hematopoietic lineages. We investigated the role of Flvcr1a in liver function in mice.
Kinetics and Specificity of Feline Leukemia Virus Subgroup C …
The feline leukemia virus subgroup C receptor (FLVCR) is a heme export protein that is required for proerythroblast survival and facilitates macrophage heme iron recycling. However, its mechanism of heme export and substrate specificity are uncharacterized.