GATA4 - Wikipedia
GATA4 is a critical transcription factor for proper mammalian cardiac development and essential for survival of the embryo. GATA4 works in combination with other essential cardiac transcription factors as well, such as Nkx2-5 and Tbx5.
GATA4 Gene - GeneCards | GATA4 Protein | GATA4 Antibody
2024年10月2日 · GATA4 (GATA Binding Protein 4) is a Protein Coding gene. Diseases associated with GATA4 include Testicular Anomalies With Or Without Congenital Heart Disease and Atrial Septal Defect 2. Among its related pathways are Gene expression (Transcription) and Cardiac conduction.
GATA4是转录因子GATA家族的重要一员，目前研究已经证实， 它对心肌肥厚的进程有着重要的影响。本文主要综述转录因子GATA4在CH和HF进程中调节机制的研究 进展。 关键词 心力衰竭，心肌肥厚，GATA4 Research Progress on the Correlation and Molecular Mechanism of …
Transcription Factor GATA4 Regulates Cell Type–Specific Splicing ...
2022年8月8日 · Here, we show that GATA4 (GATA-binding protein 4), a cardiac-enriched zinc finger–containing, DNA-binding transcription factor essential for normal cardiac development in mice and humans, and for mediation of the transcriptional response to cardiac stress, 26–28 also functions as a regulator of alternative RNA splicing.
GATA4 GATA binding protein 4 [ Homo sapiens (human) ]
2024年11月27日 · Title: GATA4 regulates the transcription of MMP9 to suppress the invasion and migration of breast cancer cells via HDAC1-mediated p65 deacetylation. Enhanced GATA4 expression in senescent systemic lupus erythematosus monocytes promotes high levels of IFNalpha production.
GATA4 GATA binding protein 4 [ (human)] - National Center for ...
GATA-4, a potential novel therapeutic target for high-grade meningioma, regulates miR-497, a potential novel circulating biomarker for high-grade meningioma. The M310T mutation in the GATA4 gene is a novel pathogenic target of the familial atrial septal defect.
GATA4 GATA binding protein 4 - NIH Genetic Testing Registry …
2024年11月5日 · Members of this family recognize the GATA motif which is present in the promoters of many genes. This protein is thought to regulate genes involved in embryogenesis and in myocardial differentiation and function, and is necessary for normal testicular development. Mutations in this gene have been associated with cardiac septal defects.
Transcription Factor GATA4 Regulates Cell Type-Specific Splicing ...
2022年8月8日 · This study shows that in addition to its well described transcriptional function, GATA4 interacts with members of the spliceosome complex and regulates cell type-specific alternative splicing via sequence-specific interactions with RNA. Several genes that have splicing regulated by GATA4 have functi …
Cell signalling pathways for the regulation of GATA4 transcription ...
GATA4 is a member of the GATA family of zinc finger transcription factor, which regulates gene transcription by binding to GATA elements. GATA4 was originally discovered as a regulator of cardiac development and subsequently identified as …
Dynamic GATA4 enhancers shape the chromatin landscape central …
2014年9月24日 · Here, we addressed this question by mapping chromatin occupancy of GATA4—a master cardiac transcription factor—in heart development and disease. We find that GATA4 binds and participates in...
- 某些结果已被删除