Germinal center - Wikipedia
Germinal centers are an important part of the B cell humoral immune response, acting as central factories for the generation of affinity matured B cells specialized in producing improved antibodies that effectively recognize antigen (e.g. infectious agents), and for the production of long-lived plasma cells and durable memory B cells.
Germinal Centers - Annual Reviews
Germinal centers (GCs) are microanatomical sites of B cell clonal expansion and antibody affinity maturation. Therein, B cells undergo the Darwinian process of somatic diversification and affinity-driven selection of immunoglobulins that produces the high-affinity antibodies essential for effective humoral immunity.
Germinal centres: role in B-cell physiology and malignancy
Key Points. The germinal centre (GC) of lymphoid organs is the main structure where antigen-activated B cells diversify their immunoglobulin genes by somatic hypermutation (SHM) to generate...
Germinal Centers - PubMed
2022年4月26日 · Germinal centers (GCs) are microanatomical sites of B cell clonal expansion and antibody affinity maturation. Therein, B cells undergo the Darwinian process of somatic diversification and affinity-driven selection of immunoglobulins that produces the high-affinity antibodies essential for effective …
Germinal Centers - Annual Reviews
Germinal centers (GCs) were described more than 125 years ago as compartments within secondary lymphoid organs that contained mitotic cells. Since then, it has become clear that this structure is the site of B cell clonal expansion, somatic hypermutation, and affinity-based selection, the combination of which results in the production of high ...
The Biology of the Germinal Center - American Society of …
2007年1月1日 · Learn how B-cells undergo somatic hypermutation and class-switch recombination in the germinal center to produce high-affinity antibodies. Explore the molecular mechanisms and gene expression signatures of germinal center B-cell lymphomas.
Germinal Center B Cell Dynamics: Immunity - Cell Press
2016年9月20日 · Germinal centers are ultrastructural sites within lymphoid tissue that support the maturation of B lymphocytes into antibody-secreting cells. In this review, Mesin et al. update the current understanding of the cellular interactions and positioning of B lymphocytes within these foci to support a humoral immune response.
Germinal Center | Complete Anatomy - Elsevier
The germinal center is found at the core of the secondary lymphoid nodule and is the site of activation, proliferation, differentiation, and death of B lymphocytes, or B-cells. Germinal centers may by present for 2–3 weeks after antigenic stimulation.
Regulation of the Germinal Center Response - PMC - National Center …
2018年10月25日 · The germinal center (GC) is a specialized microstructure that forms in secondary lymphoid tissues, producing long-lived antibody secreting plasma cells and memory B cells, which can provide protection against reinfection.
The unique biology of germinal center B cells - Cell Press
2021年8月10日 · Germinal center (GC) B cells are the source of the high-affinity, class-switched antibodies required for protective immunity. The unique biology of GC B cells involves iterative rounds of antibody gene somatic hypermutation coupled …