Cardiovascular System - Heart Development - Embryology
Our aim is to investigate whether myoarchitectural abnormalities in HCM are present in the fetal heart. We used wild-type, heterozygous and homozygous hearts (n = 56) from a Mybpc3-targeted knock-out HCM mouse model and imaged the 3D micro …
A detailed comparison of mouse and human cardiac development …
2014年8月28日 · Mouse mutants are used to model human congenital cardiovascular disease. Few studies exist comparing normal cardiovascular development in mice vs. humans. We carried out a systematic...
Mouse Heart - Embryology
3 天之前 · Excess endothelial-to-mesenchymal transition, resulting in increased mesenchymal cells, is the likely cause of morphological heart abnormalities in both humans and mice. In mice, these abnormalities result in progressive and severe diastolic dysfunction, culminating in …
Histology Atlas of the Developing Mouse Heart with Emphasis on …
2009年4月9日 · The aim of this color atlas, which demonstrates embryonic/fetal heart development, is to provide a tool for pathologists and biomedical scientists to use for detailed histological evaluation of hematoxylin and eosin (H&E)-stained sections of the developing mouse heart with emphasis on embryonic days (E) 11.5–18.5.
Single-cell transcriptomic analysis identifies murine heart …
2022年12月27日 · Heart development is a continuous process involving significant remodeling during embryogenesis and neonatal stages. To date, several groups have used single-cell sequencing to characterize...
Three-dimensional microCT imaging of mouse heart development …
2023年1月3日 · The progression of heart development during embryogenesis. In late gestation stage embryos, visualization of the heart and other internal organs becomes a challenge as these organs are within the body cavity, skin has developed, and the embryo has lost translucency, making morphological examination without dissection impossible.
Transcription factor NFYa controls cardiomyocyte metabolism and ...
2023年12月18日 · Here, we study the role of the transcription factor NFYa in developing mouse hearts. Loss of NFYa alters cardiomyocyte composition, causing a decrease in immature regenerative cells and an increase in trabecular and mature cardiomyocytes, as identified by spatial and single-cell transcriptome analyses.
Noninvasive, In Utero Imaging of Mouse Embryonic Heart Development With ...
1998年9月1日 · We report the first use of a novel 40-MHz ultrasound imaging system in the study of mouse cardiac development in utero. Methods and Results —Transabdominal scans of mouse embryos staged between 8.5 and 13.5 days of gestation (E8.5 to E13.5) were obtained in anesthetized mice.
Three-dimensional microCT imaging of mouse heart development …
2023年1月3日 · Although the heart and its development are clearly abnormal compared to litter mate controls seen by 3D rendering of the microCT data (Fig. 4B–C), the opaque spots are an unusual phenotype that could not be explained without further investigation. microCT sections show what appeared to be breaks in the myocardium of the mutant (Fig. 4G) that ...
Cardiovascular assessment of fetal mice by in utero …
Our analysis showed heart rate increased from 190 to 245 bpm as the mouse fetus grew from 8 mm at embryonic day 12.5 to 18.7 mm at term. This was accompanied by increases in peak outflow velocity, E-wave, E/A ratio and ventricular dimensions. In contrast, the A-wave, myocardial performance index and isovolemic contraction time decreased gradually.
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