Helios + and Helios - Treg subpopulations are phenotypically …
The transcription factor Helios is expressed in a large subset of Foxp3 + Tregs. We previously proposed that Helios is a marker of thymic derived Treg (tTreg), while Helios-Treg were induced from Foxp3-T conventional (Tconv) cells in the periphery (pTreg). To compare the two Treg subpopulations, we generated Helios-GFP reporter mice and crossed ...
Helios is a marker, not a driver, of human Treg stability
Using an in vitro expansion system, we found that loss of high Helios expression and emergence of an intermediate Helios (Helios mid)-expressing population correlated with Treg destabilization. We used CRISPR/Cas9 to genetically ablate Helios expression in human naive or memory Tregs and found that Helios-KO and unedited Tregs were equivalent ...
识别Treg细胞的身份，你可以这样做_免疫 - 搜狐
2020年2月20日 · Treg细胞就是调节性T细胞（regulatory T cells），是免疫系统中的基本细胞，是Sakaguchi等人 [1]于1995发现的，以表达Foxp3、CD25、CD4为细胞表型特征。 它是Th1、Th2、Th17之外的T细胞亚群，属于一类增殖能力较低的CD4+ T细胞亚群，具有免疫抑制作用，能够分泌IL-4、IL-10和TGF-β等细胞因子，在免疫稳态和诱导免疫耐受中发挥重要作用。 Treg细胞在感染、肿瘤、器官移植、预防自身免疫疾病、维持机体免疫平衡等方面具有重要作用。 1. Treg细胞 …
体外诱导的Helios ＋ 调节性T细胞的特征分析 - Yiigle.com
本研究拟对体外诱导的Helios ＋ 调节性T细胞(induced Helios ＋ regulatory T cell，Helios ＋ iTreg)的特征进行分析，并比较其与正常人外周血固有Helios ＋ Treg(natural Helios ＋ Treg, Helios ＋ nTreg)的差异。
Helios—controller of Treg stability and function - PMC
The role of Helios in maintaining Treg stability raises more intriguing questions. First, the factors that maintain Helios expression in Treg are unclear. Further elucidation of the factors that control Helios expression would help identify potential therapeutic targets to manipulate Treg stability.
Helios expression is a marker of T cell activation and ... - PubMed
Recently, the Ikaros family member, Helios, was reported as a marker to discriminate naturally occurring, thymic-derived Tregs from those peripherally induced from naïve CD4+ T cells. We investigated Helios expression in murine and human T cells under resting or activating conditions, using well-characterized molecules of naïve/effector ...
Helios Expression Is a Marker of T Cell Activation and Proliferation …
2011年8月30日 · We investigated Helios expression in murine and human T cells under resting or activating conditions, using well-characterized molecules of naïve/effector/memory phenotypes, as well as a set of Treg-associated markers. We found that Helios-negative T cells are enriched for naïve T cell phenotypes and vice versa.
Helios+ and RORγt+ Treg populations are differentially regulated …
2023年6月1日 · Our data show that intestinal Helios + and RORγt + Tregs possess unique responses to costimulatory signals and might compete for access to APC signals in the intestinal niche. When ICOS signals are reduced, the RORγt + Treg subpopulation shrinks, Helios + Tregs gain more access to
Helios+ 和 RORγt+ Treg 群体受到 MHCII、CD28 和 ICOS 的差异调节，以形成肠道 Treg …
Foxp3+ 调节性 T 细胞 (Treg) 对于肠道稳态至关重要。 小肠中的 Tregs 包括 Helios+ 胸腺衍生的 Tregs (tTregs) 和抗原刺激后在外周分化的 RORγt+ Tregs (pTregs)。 TCR 和共刺激信号维持具有效应表型的 Treg，包括肠道中的 TTreg，但尚不清楚 tTreg 和 pTreg 对这些途径是否有类似的 ...
Helios Controls a Limited Subset of Regulatory T Cell Functions
2016年1月1日 · We show that the selective deletion of Helios in Tregs leads to slow, progressive systemic immune activation, hypergammaglobulinemia, and enhanced germinal center formation in the absence of organ-specific autoimmunity. Helios-deficient Treg suppressor function was normal in vitro, as well as in an in vivo inflammatory bowel disease model.