Holoprosencephaly (HPE) is a birth defect (congenital condition) that causes the fetal brain to not properly separate into the right and left hemispheres (halves). HPE ranges in severity and also often causes facial development issues.

What is Holoprosencephaly? Holoprosencephaly (HPE) is a condition that changes the way a baby’s brain develops. In HPE, the left and right sides of the brain do not separate like they should. The severity of HPE depends on how much of the brain separated properly.

2024年6月7日 · Holoprosencephaly (HPE) results from an incomplete midline cleavage of the forebrain (prosencephalon). It includes a wide spectrum of intracranial and craniofacial midline defects and a myriad of clinical manifestations, consisting of neurologic impairment and dysmorphism of the brain and face.

Holoprosencephaly is an abnormality of brain development in which the brain doesn't properly divide into the right and left hemispheres. The condition can also affect development of the head and face. There are 4 types of Holoprosencephaly, distinguished by severity.

2018年5月9日 · Holoprosencephaly (HPE) is the failure of the prosencephalon, or forebrain, to develop normally. The forebrain is a region of the brain in the fetus that develops into parts of the adult brain, including the cerebral cortex.

6 天之前 · Holoprosencephaly (HPE) is a rare congenital brain malformation resulting from incomplete separation of the two hemispheres. Classically three subtypes have been recognized, however additional entities are now included in the spectrum of the disease.

2025年2月4日 · Holoprosencephaly (HPE) is the most common birth defect of the forebrain (i.e., prosencephalon) and presents with manifestations of underdevelopment of the brain with a wide range of severity. More specifically, HPE is characterized by a failure of the forebrain to properly divide into two distinct cerebral hemispheres.

2000年12月27日 · Holoprosencephaly (HPE), the most common malformation of the forebrain in humans, is a structural anomaly of the brain resulting from failed or incomplete forebrain division in the third to fourth weeks of gestation; the forebrain (prosencephalon) incompletely cleaves into right and left hemispheres, deep brain structures, and the olfactory and ...

Alobar and lobar holoprosencephaly are associated with microcephaly and midfacial defects in 80% of cases. Extracerebral defects are particularly common in fetuses with trisomies 13 and 18 and those with genetic syndromes.

Holoprosencephaly (HPE) is a rare birth defect. Early in pregnancy, a baby’s brain ordinarily separates into two sections. This does not happen completely in children with HPE. The cause of HPE is unknown but may include genetic disorders.