『腺病毒』入门知识介绍-结构、感染过程、Ad5 & Ad5/F35、Adv …
腺病毒(Adenovirus，Ad)是一种无包膜的DNA病毒，其复制不依赖于宿主细胞的分裂。腺病毒有50余种血清型，大多数腺病毒载体是基于血清型2和血清型5，通过转基因的方式取代E1和E3基因，降低病毒的复制能力。
Human Adenovirus 5 - an overview | ScienceDirect Topics
The DNA virus, human adenovirus 5 (Ad5), expresses small E1A (e1a) and large E1A proteins that coordinate the regulation of different sets of viral promoters, activate viral genes, and reprogram the host environment to achieve efficient viral replication. e1a is an oncogene that derepresses genes that drive G1 arrested cells into S phase [52 ...
Human Adenovirus 5 - an overview | ScienceDirect Topics
For historical reasons and because of its extended use in the viral vector field, human adenovirus type 5 (HAdV-C5) is the best characterized member of the adenovirus family.
Human Adenovirus Type 5 Infection Leads to Nuclear Envelope ... - PubMed
2021年12月2日 · The human adenovirus type 5 (HAdV5) infects epithelial cells of the upper and lower respiratory tract. The virus causes lysis of infected cells and thus enables spread of progeny virions to neighboring cells for the next round of infection. The mechanism of adenovirus virion egress across the nuclea …
Human Adenovirus 5 - an overview | ScienceDirect Topics
Human adenovirus 5 (Ad5 together with Ad2 belong to the species C of the family Adenoviridae) is a non-enveloped virus with stable double-stranded linear DNA genome (≈36 kilobase pairs in length), which shows a low rate of spontaneous mutagenesis (1.3 × 10 −7 per base per cell infection cycle) (Risso-Ballester et al., 2016).
Human Adenovirus Type 5 Infection Leads to Nuclear Envelope ...
2021年12月2日 · The human adenovirus type 5 (HAdV5) infects epithelial cells of the upper and lower respiratory tract. The virus causes lysis of infected cells and thus enables spread of progeny virions to neighboring cells for the next round of infection. The mechanism of adenovirus virion egress across the nuclear barrier is not known.
Recombinant human adenovirus type 5 promotes anti-tumor
2024年7月19日 · Recombinant human type 5 adenovirus (H101) is an oncolytic virus used to treat nasopharyngeal carcinoma. Owing to the deletion of the E1B-55kD and E3 regions, H101 is believed to selectively...
Deep splicing plasticity of the human adenovirus type 5 ... - Nature
2020年3月13日 · Here, dRNA-seq was used to examine the transcriptome of human adenovirus type 5 during an infection, revealing an unbiased picture of the viral transcriptome in unparalleled detail; almost...
Human Adenovirus Serotype 5 Is Sensitive to IgM-Independent ...
2019年7月5日 · Human adenovirus 5 (HAdV-5) is used as a vector in gene therapy clinical trials, hence its interactions with the host immune system have been widely studied. Previous studies have demonstrated that HAdV-5 binds specifically to murine coagulation factor X (mFX), inhibiting IgM and complement-mediated neutralization.
High-Throughput Screening and Identification of Human Adenovirus Type 5 ...
2021年12月17日 · In this study, a chemiluminescence-based, high-throughput screening (HTS) assay was developed and applied to screen human adenovirus 5 (HAdV5)inhibitors from 1,813 approved drug library and 556 traditional Chinese medicine-sourced small-molecule compounds.