Induced pluripotent stem cell - Wikipedia
Induced pluripotent stem cells (also known as iPS cells or iPSCs) are a type of pluripotent stem cell that can be generated directly from a somatic cell.
Induced pluripotent stem cells (iPSCs): molecular mechanisms of ...
2024年4月26日 · The induced pluripotent stem cell (iPSC) technology has transformed in vitro research and holds great promise to advance regenerative medicine. iPSCs have the capacity for an almost...
Induced Pluripotent Stem Cells: Problems and Advantages …
Induced pluripotent stem cells (iPSCs) are a new type of pluripotent cells that can be obtained by reprogramming animal and human differentiated cells. In this review, issues related to the nature of iPSCs are discussed and different methods of iPSC production are described.
Induced pluripotent stem cells | UCLA BSCRC
Induced pluripotent stem cells are derived from skin or blood cells that have been reprogrammed back into an embryonic-like pluripotent state that enables the development of an unlimited source of any type of human cell needed for therapeutic purposes.
induced pluripotent stem cell - Encyclopedia Britannica
2024年10月27日 · induced pluripotent stem cell (iPS cell), immature cell that is generated from an adult (mature) cell and that has regained the capacity to differentiate into any type of cell in the body.
How iPS cells changed the world - Nature
2016年6月15日 · Induced pluripotent stem cells were supposed to herald a medical revolution. But ten years after their discovery, they are transforming biological research instead. Shinya Yamanaka won a Nobel...
What are iPS cells? | For the Public | CiRA | Center for iPS Cell ...
Induced pluripotent stem cells (iPSCs) are a new type of pluripotent stem cells first generated in 2006 in mouse. They represent a potentially important resource for applications in regenerative medicine. In this section, we will look at how iPSCs are made, why they may be important, and how they might one day make contributions in medicine.
Induced Pluripotent Stem Cells: Reprogramming Platforms and ...
The generation of induced pluripotent stem cells (iPSCs) from differentiated mature cells is one of the most promising technologies in the field of regenerative medicine. The ability to generate patient-specific iPSCs offers an invaluable reservoir ...
Personalized iPSC-Derived Dopamine Progenitor Cells for Parkinson…
2020年5月13日 · We report the implantation of patient-derived midbrain dopaminergic progenitor cells, differentiated in vitro from autologous induced pluripotent stem cells (iPSCs), in a patient with...
Research and therapy with induced pluripotent stem cells (iPSCs ...
2019年11月21日 · Induced pluripotent stem cells (iPSCs) are artificial stem cells produced from somatic cells through co-expression of defined pluripotency-associated factors [1, 2]. Like embryonic stem cells (ESCs), they can typically proliferate and self-renew indefinitely in vitro and differentiate into derivatives of all three primary germ layers (i.e ...
Human Induced Pluripotent Stem Cells - ATCC
Induced pluripotent stem cells (iPSCs) provide a powerful starting material to model human disease in relevant cell types. iPSCs may be generated from patients of any genetic background and possess the capacity to differentiate into almost any desired terminal cell type.
Induced pluripotent stem cells: Generation methods and a new ...
Induced pluripotent stem cells (iPSCs) exhibit an unlimited ability to self-renew and produce various differentiated cell types, thereby creating high hopes for both scientists and patients as a great tool for basic research as well as for regenerative medicine purposes.
Methods for making induced pluripotent stem cells ... - Nature
2011年2月22日 · These induced pluripotent stem cells (iPSCs) are relevant to a range of applications, including: autologous cell therapy; the modelling of monogenic and multigenic diseases; the study of...
Induced Pluripotent Stem Cell - an overview - ScienceDirect
Induced pluripotent stem (iPS) cells, commonly abbreviated as iPS cells or iPSCs, are a type of pluripotent stem cell artificially derived from a non-pluripotent cell, an adult somatic cell, by a “forced” expression of certain genes. You might find these chapters and articles relevant to …
Induced pluripotent stem cell technology: a decade of progress
Since the advent of induced pluripotent stem cell (iPSC) technology a decade ago, enormous progress has been made in stem cell biology and regenerative medicine. Human iPSCs have been widely used for disease modelling, drug discovery and cell therapy development.
Generation of Functional iPSC-Derived CAR-T Cells for Cancer ...
2024年11月5日 · Single-cell RNA-seq analysis further revealed that iPSC-derived T cells give rise to both effector and memory-like T cell subpopulations upon activation. When these epigenetically reprogrammed iPSC-derived T cells were engineered to express an anti-CD19 CAR, they showed potent effector responses and antitumor activity in vitro and in a ...
Mapping the global landscape for induced pluripotent stem cells …
2024年4月17日 · The modeling process using iPSCs involves isolating somatic cells from patients, reprogramming them into iPSCs, and then differentiating them into disease-related cell types to recapitulate...
Induced pluripotent stem cells, past and future | Science - AAAS
2016年9月2日 · By showing that a set of transcription factors could reprogram somatic cells to acquire a pluripotent stem cell state, they ushered in the era of induced pluripotent stem cells (iPSCs).
Induced pluripotent stem cells, a giant leap for mankind …
Induced pluripotent stem cells (iPSC) technology has propelled the field of stem cells biology, providing new cells to explore the molecular mechanisms of pluripotency, cancer biology and aging.
Human iPSC-derived myelinating organoids and globoid cells to …
2 天之前 · iPSC-derived microglia were produced as described previously . iPSCs were dissociated to single cell suspension with Accutase ® (Sigma, A6964) for 2–3 min. in the incubator and plated onto 8.6 μg/cm 2 Matrigel (Corning, 356234) coated dishes at a density of 1.5x10 3 cells/cm 2 in mTeSR-Plus media containing 10μM Rock Inhibitor for 24 hrs.
Induced pluripotent stem cell technology: a decade of progress
2016年12月16日 · Human iPSCs have been widely used for disease modelling, drug discovery and cell therapy development. Novel pathological mechanisms have been elucidated, new drugs originating from iPSC...
Making blood from iPSCs: Reaching for the most sought ... - Cell …
2 天之前 · Recently, Piau et al. achieved the generation of serially transplantable HSCs in vitro from iPSC lines that were capable of multi-lineage engraftment. 10 The protocol was also reproduced in an independent laboratory setting (in the same paper). A major difference of the Ng et al. protocol is the gradual specification of different cell types compared to a one-step …
CD19 CAR-expressing iPSC-derived NK cells effectively enhance
In cancer immunotherapy, chimeric antigen receptors (CARs) targeting specific antigens have become a powerful tool for cell-based therapy. CAR-natural killer (NK) cells offer selective anticancer lysis with reduced off-tumor toxicity compared to CAR-T cells, which is beneficial in the heterogeneous …
Induced pluripotent stem cells - Latest research and news - Nature
2024年11月19日 · Induced pluripotent stem cells (iPSCs) are pluripotent stem cells generated from adult cells by reprogramming. iPSCs have the same properties as embryonic stem cells, and therefore...