The unique properties of IgG4 and its roles in health and disease
2023年4月24日 · IgG4 is the least abundant subclass of IgG in human serum and has unique functional features. IgG4 is largely unable to activate antibody-dependent immune effector responses and, furthermore,...
IgG4-related disease—rare but you should not forget it
2024年5月3日 · Immunoglobulin G4-related disease is a systemic immune-mediated disease with insidious evolution characterized by fibroinflammatory lesions over virtually any organ system. Despite the remarkable progression of knowledge, its etiology remains undefined.
IgG4-Related Disease - StatPearls - NCBI Bookshelf
2023年8月8日 · IgG4-related disease (IgG4-RD) is known as an IgG4-related systemic disease, hyper-IgG4 disease, IgG4-related autoimmune disease, IgG4-associated disease, IgG4-related sclerosing disease, and IgG4-syndrome. It is a multi-organ, fibro-inflammatory condition with tumefactive lesions of unknown etiology and characteristic histopathological features.
IgG4-Related Disease - IgG4-Related Disease - The Merck …
Immunoglobulin G4-related disease (IgG4-RD) is a chronic immune-mediated fibroinflammatory disorder that often manifests with tumor-like masses and/or painless enlargement of multiple organs. Serum IgG4 level is often but not always elevated. Symptoms depend on which organs are affected. Diagnosis generally requires biopsy.
IgG4-related sclerosing disease: Symptoms, treatment, and more
2 天之前 · IgG4-related sclerosing disease is an immune-mediated disease that affects multiple organs at the same time in some people. This can often include an inflamed pancreas, organ swelling, disease in ...
IgG4 Autoantibodies in Organ-Specific Autoimmunopathies: …
Antibodies involved in IgG4-AID, known to date, target antigens in mainly four organ systems: 1) the central and peripheral nervous system with diseases such as MuSK myasthenia gravis (MG), anti-LGI1 and anti-Caspr2 encephalitis, anti-IgLON5 disease or chronic inflammatory demyelinating polyneuropathy (CIDP) with antibodies against NF155/contact...
IgG4- related disease: an orphan disease with many faces
2014年7月16日 · However, IgG4-RD can affect any organ such as salivary glands, orbits, retroperitoneum and many others. Recent research enabled a clear clinical and histopathological description of IgG4-RD. Typically, lymphoplasmacellular inflammation, storiform fibrosis and obliterative phlebitis are found in IgG4-RD biopsies and the tissue invading plasma ...
IgG4 Autoantibodies in Organ-Specific Autoimmunopathies: …
2022年3月24日 · A subgroup of autoimmunopathies has recently emerged that is characterized by predominant autoantibodies of the IgG4 subclass (IgG4-autoimmune diseases; IgG4-AID). This group includes pemphigus vulgaris, thrombotic thrombocytopenic purpura, subtypes of autoimmune encephalitis, inflammatory neuropathies, …
Organ Correlation in IgG4-Related Diseases - PubMed
IgG4-related disease (IgG4-RD) is a potentially multiorgan disorder. In this study, clinical and serological features from 132 IgG4-RD patients were compared about organ correlations. Underlying pathologies comprised autoimmune pancreatitis (AIP) in 85 cases, IgG4-related sclerosing cholangitis (IgG …
IgG4-related disease: an update on pathophysiology and ... - Nature
2020年9月16日 · IgG4-related disease (IgG4-RD) is an insidiously progressive immune-mediated fibrotic disease typified by tumour-like mass formation in many affected organs. High serum IgG4 concentrations or ...
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