Is continuous infusion of imipenem always the best choice?
For the target of 40%fT >MIC, all 0.5-h infusion regimens achieved optimal exposures (CFR ≥ 90%) against Escherichia coli and Staphylococcus aureus, with nearly optimal exposure …
Extended infusion versus intermittent infusion of imipenem in …
2017年9月6日 · Extended infusion was implemented to improve the PK/PD profile of imipenem as a means to maximize its therapeutic benefit against imipenem-responsive gram-negative …
Prolonged infusions of beta-lactam antibiotics - UpToDate
2024年8月22日 · Prolonged infusion administration strategies for intravenous beta-lactam antibiotics may include either a continuous infusion (over the entire dosing interval) or an …
Primaxin (imipenem/cilastatin) dosing, indications, interactions ...
Administer doses ≤ 500 mg by IV infusion over 20-30 min; Administer doses >500 mg by IV infusion over 40-60 min; In patients who develop nausea during the infusion, rate of infusion …
Cilastatin / Imipenem Dosage Guide + Max Dose, Adjustments - Drugs.com
2023年9月7日 · Detailed Cilastatin / Imipenem dosage information for adults and children. Includes dosages for Bacterial Infection, Urinary Tract Infection, Bronchitis and more; plus …
International consensus recommendations for the use of …
2023年8月24日 · The investigators combined the mechanism-based combination PD model with the published PK models of tobramycin and imipenem in critically ill patients, and simulated …
Is continuous infusion of imipenem always the best choice?
2017年3月1日 · Extended infusions of imipenem provide better probability of target attainment (PTA). Continuous infusion carries a risk of failing to reach bacteriostatic targets. Cumulative …
Continuous vs bolus administration of imipenem in critically ill ...
2004年3月15日 · We randomized 20 critically ill patients with ICU-acquired pneumonia to receive imipenem either 2 g/24 hours by continuous infusion (CON, n = 10) or bolus dosing (1 g every …
Influence of Concentration and Temperature on Stability of Imipenem …
2021年11月23日 · When imipenem is administered by extended infusion, it is recommended to be diluted to low concentration (≤5 mg/mL); higher concentration such as 10 mg/mL should be …
Imipenem/Cilastatin Monograph for Professionals - Drugs.com
2023年12月4日 · Following a 500-mg or 1-g dose of imipenem (given as imipenem/cilastatin by IV infusion over 20 minutes), peak plasma concentrations of imipenem antimicrobial activity …