Interleukin - StatPearls - NCBI Bookshelf - National Center for ...
2022年8月22日 · Interleukins (IL) are a type of cytokine first thought to be expressed by leukocytes alone but have later been found to be produced by many other body cells. They play essential roles in the activation and differentiation of immune cells, as well as proliferation, maturation, migration, and adhesion.
THE INTERLEUKIN-1 FAMILY: BACK TO THE FUTURE - PMC
Interleukin-1 (IL-1) is a central mediator of innate immunity and inflammation. The IL-1 family includes 7 ligands with agonist activity (IL-1α and β, IL-18, IL-33, IL-36α, β, γ), three receptor antagonists (IL-1Ra, IL-36Ra, IL-38) and an anti-inflammatory cytokine (IL-37).
The IL-1 family: regulators of immunity - Nature
2010年1月18日 · The interleukin-1 (IL-1) cytokine family comprises 11 members: IL-1α, IL-1β, IL-1 receptor antagonist (IL-1Ra), IL-18, IL-33 and IL-1F5–IL-1F10. The biology of...
Interleukins (from IL-1 to IL-38), interferons, transforming growth ...
2016年8月28日 · Secreted proteins that bind to their specific receptors and play a role in intercellular communication among leukocytes are named interleukins.
Overview of the IL-1 family in innate inflammation and acquired ...
IL-37, a member of the IL-18 subfamily, was first reported in 2000 using in silico research 179 and given the name for IL-1 family 7 (IL-1F7); this name was changed to IL-37 during the revision of interleukin-1 family nomenclature. 160 There are 4 IL-37 isoforms due to exon deletions and IL-37b is the most complete form. 180 Most studies with ...
The Interleukin-1 Family: Back to the Future - ScienceDirect
2013年12月12日 · Interleukin-1 (IL-1) is a central mediator of innate immunity and inflammation. The IL-1 family includes seven ligands with agonist activity (IL-1α and IL-1β, IL-18, IL-33, IL-36α, IL-36β, IL-36γ), three receptor antagonists (IL-1Ra, IL-36Ra, IL-38), and an anti-inflammatory cytokine (IL-37).
Interleukin 12 (IL-12) Family Cytokines: Role in Immune Pathogenesis ...
Interleukin 12 (IL-12) family is comprised of 4 members, IL-12, IL-23, IL-27 and IL-35. IL-12, IL-23 and IL-27 are secreted by activated antigen presenting cells (APC) during antigen presentation to naïve T cells while IL-35 is a product of regulatory T and B cells [1–3].
Evolutionary divergence and functions of the human interleukin …
2010年10月1日 · Interleukins initiate a response by binding to high-affinity receptors located on the surface of cells; ILs act in a paracrine or autocrine fashion, rather than as an endocrine signal, which is more common with steroidal and amino acid-derived hormones.
Introduction to the Interleukin-1 Family of Cytokines and …
More than any other family, the IL-1 Family of 11 cytokines and 10 receptors provides the host with an endogenous innate immune system, whereas the family of Toll-like Receptors (TLR) provides the host with an exogenous innate system.
Interleukin 1 Family - an overview | ScienceDirect Topics
The interleukin-1 family of cytokines are central to the pathology of acute and chronic diseases of the central nervous system. We describe current evidence on the transcriptional and post-transcriptional regulation of interleukin-1β production, secretion and activity in the brain.
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