LRP1 - Wikipedia
Low density lipoprotein receptor-related protein 1 (LRP1), also known as alpha-2-macroglobulin receptor (A2MR), apolipoprotein E receptor (APOER) or cluster of differentiation 91 (CD91), is a protein forming a receptor found in the plasma membrane of …
LRP1 Gene - GeneCards | LRP1 Protein | LRP1 Antibody
2024年12月25日 · LRP1 (LDL Receptor Related Protein 1) is a Protein Coding gene. Diseases associated with LRP1 include Developmental Dysplasia Of The Hip 3 and Keratosis Pilaris Atrophicans. Among its related pathways are Visual phototransduction and Statin inhibition of cholesterol production.
The LDL Receptor-Related Protein 1: Mechanisms and
2025年1月1日 · The LDL Receptor-Related Protein 1(LRP1), a member of the Low-density Lipoprotein (LDL) receptor family, is a multifunctional cellular transporter and signaling receptor, this includes regulation of lipid metabolism, cell migration and signaling.
低密度脂蛋白受体相关蛋白1在阿尔茨海默病中的研究进展
2014年11月6日 · 载脂蛋白E (apolopoprotein,ApoE) [2] 与低密度脂蛋白受体相关蛋白1 (low-density lipoprotein receptor-related protein 1,LRP1) [3] 均对脑内Aβ的清除起到重要作用。 1 概述. LRP1是一种内吞受体，属于低密度脂蛋白 (low-density lipoprotein,LDL)受体家族成员。 这类受体家族的成员都是细胞表面受体并参胆固醇代谢、胞内运输及细胞信号传导等过程，且在突触可塑性和神经元发育方面起到重要作用。 LRP1的分子量为600 kDa，它能够结合约40种功能和结构 …
Nature：神经退行性疾病治疗下一个新靶点——LRP1 - 知乎
Tau蛋白通常存在于我们的脑细胞中，它可以维持神经元的结构及其稳定性，并且有助于营养物质在细胞中的转移。 然而，tau蛋白与 额颞痴呆 、阿尔茨海默症和慢性创伤性脑病等神经退行性疾病也有着密切联系。 当tau发生错误折叠时会变得粘稠且不溶，在神经元内发生聚集并形成 神经原纤维缠结，破坏神经元功能并最终导致神经元死亡，而且仅需少量发生错误折叠的tau蛋白，即可将其相邻脑细胞转变为功能异常、垂死的细胞。 加州大学圣塔芭芭拉分校 的神经科学家Kenneth …
The molecular mechanism of LRP1 in physiological vascular …
2021年7月1日 · Low-density lipoprotein (LDL) receptor-related protein-1 (LRP1), a transmembrane receptor protein belonging to the LDL receptor family, plays multifunctional roles in maintaining endocytosis, homeostasis, and signal transduction.
LRP1 is a master regulator of tau uptake and spread - Nature
2020年4月1日 · Here we show that the low-density lipoprotein receptor-related protein 1 (LRP1) controls the endocytosis of tau and its subsequent spread. Knockdown of LRP1 significantly reduced tau...
The low density lipoprotein receptor-related protein 1: Unique …
The low-density lipoprotein (LDL) receptor-related protein (originally called LRP, but now referred to as LRP1) is a large endocytic receptor that is widely expressed in several tissues. LRP1 is a member of the LDL receptor family that plays diverse ...
LRP1 and its interacting partners in tissue homeostasis - PMC
LDL receptor-related protein 1 (LRP1) is a multi-functional protein with endocytic and signal transduction properties due to its interaction with numerous extracellular ligands and intracellular proteins. This brief review highlights key ...
LRP1 is a neuronal receptor for α-synuclein uptake and spread
2022年9月2日 · We identified LRP1 as a key regulator of α-Syn neuronal uptake, as well as an important mediator of α-Syn spread in the brain. This study provides new knowledge on the physiological and pathological role of LRP1 in α-Syn trafficking and pathology, offering insight for the treatment of synucleinopath …