A liposome is a small artificial vesicle, spherical in shape, having at least one lipid bilayer. [2] Due to their hydrophobicity and/or hydrophilicity, biocompatibility, particle size and many other properties, [ 2 ] liposomes can be used as drug delivery vehicles for administration of pharmaceutical drugs and nutrients , [ 3 ] such as lipid ...

2018年2月26日 · A liposome is a closed, spherical lipid bilayer, which forms an internal cavity capable of carrying aqueous solutions. A lipid bilayer is composed of two sheets of tightly arranged phospholipids. These molecules have a hydrophobic tail and a hydrophilic head region.

2024年9月17日 · Explore the science behind liposome formation and stability, how they improve drug delivery, and their applications in cancer therapy, gene therapy, and vaccines.

2024年4月8日 · What is Liposome? Liposomes, derived from the Greek words “lipo” (fat) and “soma” (body), are spherical vesicles characterized by at least one lipid bilayer. These structures are primarily composed of phospholipids, notably …

2025年1月31日 · The liposome was modified with folate in the surface to specifically target at M2 tumor-associated macrophages and NSCLC cells, and the liposome exhibited specific targeting ability and controlled release ability . A topotecan liposome was modified with folate and exhibited improved therapeutic efficacy against A549 lung cancer cells .

2013年2月22日 · Liposome involves an aqueous core entrapped by one or more bilayers composed of natural or synthetic lipids. They are composed of natural phospholipids that are biologically inert and feebly immunogenic, and they have low inherent toxicity.

Liposome increases the efficacy and therapeutic index of drugs, like actinomycin-D. [8] Liposomes have increased stability due to encapsulation. Liposomes are non-toxic, biocompatible, non-immunogenic for systemic and non-systemic administrations.

2015年11月30日 · (A) Conventional liposome—Liposomes consist of a lipid bilayer that can be composed of cationic, anionic, or neutral (phospho)lipids and cholesterol, which encloses an aqueous core. Both the lipid bilayer and the aqueous space can incorporate hydrophobic or hydrophilic compounds, respectively.

2023年12月26日 · Liposome-associated nanotechnology has shown to protect mRNA from degradation and extend the circulatory half-life, as well as enhance the vaccination effects. Thus, liposome/lipid-based nanoplatforms represent promising strategies for …

2024年8月20日 · Furthermore, this method enhances protection against phospholipid oxidation and increases liposome stability. 79 In a study by Tan et al, the use of chitosan and alginate as polyelectrolytes in an LBL liposome system demonstrated superior stability compared to uncoated liposomes and monolayer-coated liposomes. Chitosan, with its positive charge ...