Macrophages in immunoregulation and therapeutics
2023年5月22日 · Functions of activated macrophages Phagocytosis. Phagocytosis is an essential function achieved by macrophages to satisfy their crucial purpose in removing disease and remodeling tissues.
Phagocytosis: Our Current Understanding of a Universal …
2020年6月2日 · Phagocytosis is a cellular process for ingesting and eliminating particles larger than 0.5 μm in diameter, including microorganisms, foreign substances, and apoptotic cells. Phagocytosis is found in many types of cells and it is, in consequence an essential process for tissue homeostasis.
Macrophages: From Simple Phagocyte to an Integrative …
2023年1月11日 · Macrophages are regulators in inflammatory and immunological processes within the tissue, and there are several aspects of tissue engineering in which macrophages play a pivotal role with respect to biomaterials. Relevant examples are the induction of inflammation and host responses as a reaction to biomaterial implants [8,31,48,203,204].
The Phagocytic Function of Macrophage-Enforcing Innate …
2017年12月29日 · Macrophages, the major population of tissue-resident mononuclear phagocytes, play key roles in bacterial recognition and elimination as well as in polarization of innate and adaptive immunity. Macrophages sometimes play a role in anti-inflammatory responses, tissue repair, and homeostasis while they …
Macrophage phagocytosis assay with reconstituted target …
2020年6月19日 · Macrophage phagocytosis can be triggered by diverse receptor-ligand interactions to clear pathogens and dead cells from a host. Many ways of assaying phagocytosis exist that utilize a variety...
Mechanisms of phagocytosis in macrophages - PubMed
Phagocytosis of pathogens by macrophages initiates the innate immune response, which in turn orchestrates the adaptive response. In order to discriminate between infectious agents and self, macrophages have evolved a restricted number of phagocytic receptors, like the mannose receptor, that recogniz ….
Phagocytosis: An Immunobiologic Process - Cell Press
2016年3月15日 · Phagocytosis, defined as the cellular uptake of particulates (>0.5 μ) within a plasma-membrane envelope, is closely related to and partly overlaps the endocytosis of soluble ligands by fluid-phase macropinocytic and receptor pathways.
Macrophages and the maintenance of homeostasis
2020年9月15日 · Macrophage phagocytosis allows the removal and recycling of enormous numbers of dead cells and tissue debris, which would prevent organ function if they were allowed...
Autophagy and Macrophage Functions: Inflammatory Response and Phagocytosis
2019年12月27日 · Specifically, the roles of autophagy in pattern recognition, cytokine release, inflammasome activation, macrophage polarization, LC3-associated phagocytosis, and xenophagy are comprehensively reviewed. The roles of autophagy receptors in the macrophage function regulation are also summarized.
Targeting macrophage-mediated tumor cell phagocytosis: An …
2022年2月1日 · The present study reviews macrophage phagocytosis regulation in response to tumors. •. This review outlines recent advances of modulating macrophage phagocytosis in cancers. •. We concentrate on the emerging role of CAR …