A metalloproteinase, or metalloprotease, is any protease enzyme whose catalytic mechanism involves a metal. An example is ADAM12 which plays a significant role in the fusion of muscle cells during embryo development, in a process known as myogenesis. Most metalloproteases require zinc, but some use cobalt.

给大家讲一个比较重要的酶：基质金属蛋白酶。这个酶在我们身体里面扮演了很重要的角色，今天我们从面部护肤的角度来透视一下这个酶。本文较多引用自： 基质金属蛋白酶（Matrix metalloproteinases、MMPs）皮肤病学…

金属蛋白酶（英語： metalloproteinase 或 metalloprotease ）是指任意催化机理涉及金属离子的蛋白酶，例如基质金属蛋白酶，可以分解各种细胞外基质蛋白。 大部分的金属蛋白酶需要 锌 离子作为 辅基 ，但有一些使用 钴 。

Background . Thermolysin (TLN; EC 3.4.24.27, Figure 1) is a 34.6 kDa Zn 2+-endopeptidase secreted by the bacterium Bacillus thermoproteolyticus. 8,9 TLN and TLN-like proteins are used by bacteria to break down exogenous proteins for nutrition and as virulence factors aiding in host colonization and tissue degradation. 10,11 TLN is active in the hydrolysis of internal peptide bonds on the N ...

metalloprotease 这种 酶 在 纯化 过程中始终保留定量金属离子，用一般方法不能将其除去。 但如纯化过程中有 螯合剂 如 EDTA 等存在时，也会失去金属离子从而失去 酶活性 。

Mizoguchi H., Takuma K., Fukuzaki E., Ibi D., Someya E., Akazawa K.H., Alkam T., Tsunekawa H., Mouri A., Noda Y., et al. Matrix metalloprotease-9 inhibition improves amyloid beta-mediated cognitive impairment and neurotoxicity in mice. J. Pharmacol.

2013年8月23日 · Bradley, L. M., Douglass, M. F., Chatterjee, D., Akira, S. & Baaten, B. J. Matrix metalloprotease 9 mediates neutrophil migration into the airways in response to influenza virus-induced toll-like...

基质金属蛋白酶（matrix metalloproteinase），基质金属蛋白酶是一个大家族，因其需要Ca2+、Zn2+等金属离子作为辅助因子而得名。其家族成员具有相似的结构，一般由5个功能不同的结构域组成 :（1）疏水信号肽序列;（2）前肽区，主要作用是保持酶原的稳定。当该区域被外源性酶切断后，MMPs酶原被激活 ...

Volume 1. Teruyo Nakatani, Nicola C. Partridge, in Principles of Bone Biology (Fourth Edition), 2020. Metalloproteinases. MMPs are a family of zinc- and calcium-dependent neutral endoproteinases. MMPs are responsible for remodeling the extracellular matrix (ECM), which is necessary for physiological events such as angiogenesis, wound healing, and bone development (Page-McCaw et al., 2007).

Metalloproteases (metallopeptidases) are composed of a diverse group of endopeptidases and exopeptidases. Because metalloproteases play key roles in many normal biological processes, their aberrant activities have been implicated in diseases such as arthritis, cancer, cardiovascular diseases, nephritis, disorders in the central nervous system, fibrosis, and …