The microcirculation is the motor of sepsis - Critical Care
2005年8月25日 · The presence of microcirculatory distress, despite resuscitation based on hemodynamic and oxygen-derived endpoints, strongly suggests that microcirculatory failure is a key factor in the raised lactate levels, disturbed acid–base balance, and high gastric and/or oral CO 2 levels sometimes seen under such conditions.
The future of intensive care: the study of the microcirculation will ...
2023年5月16日 · This is essential because clinical studies in different states of shock both in adult and pediatric patients have consistently shown that the persistence of microcirculatory alterations with lost of coherence between macrocirculation and microcirculation is predictive of organ failure and unfavorable outcomes in a more sensitive and specific manner than systemic …
A guide to human in vivo microcirculatory flow image analysis
2016年2月10日 · Various noninvasive microscopic camera technologies have been used to visualize the sublingual microcirculation in patients. We describe a comprehensive approach to bedside in vivo sublingual microcirculation video image capture and analysis techniques in the human clinical setting. We present a user perspective and guide suitable for clinical …
Microcirculatory perfusion disturbances in septic shock: results …
2018年11月20日 · Background We sought to determine the effects of alternative resuscitation strategies on microcirculatory perfusion and examine any association between microcirculatory perfusion and mortality in sepsis. Methods This was a prospective, formally designed substudy of participants in the Protocolized Care in Early Septic Shock (ProCESS) trial. We recruited from …
Microcirculatory assessment of patients under VA-ECMO
2016年10月25日 · Microcirculatory parameters were divided into two categories: small vessels, defined as having a diameter of 25 μm or less (for example, TVD small vessel, PVD small vessel); and all vessels, defined as having small vessels and large vessels (>25–100 μm diameter; TVD all vessel, PVD all vessel) according to the consensus on microcirculatory ...
How to evaluate the microcirculation: report of a round table ...
2007年9月10日 · Introduction Microvascular alterations may play an important role in the development of organ failure in critically ill patients and especially in sepsis. Recent advances in technology have allowed visualization of the microcirculation, but several scoring systems have been used so it is sometimes difficult to compare studies. This paper reports the results of a …
Microcirculatory perfusion disturbances following …
2020年5月13日 · Background Microcirculatory perfusion disturbances are associated with increased morbidity and mortality in patients undergoing cardiac surgery with cardiopulmonary bypass (CPB). Technological advancements made it possible to monitor sublingual microcirculatory perfusion over time. The goal of this review is to provide an overview of the …
Bench-to-bedside review: Sepsis is a disease of the …
2004年6月16日 · Microcirculatory perfusion is disturbed in sepsis. Recent research has shown that maintaining systemic blood pressure is associated with inadequate perfusion of the microcirculation in sepsis. Microcirculatory perfusion is regulated by an intricate interplay of many neuroendocrine and paracrine pathways, which makes blood flow though this microvascular …
Association of sublingual microcirculation parameters and …
2019年7月24日 · Background The endothelial glycocalyx (eGC) covers the luminal surface of the vascular endothelium and plays an important protective role in systemic inflammatory states and particularly in sepsis. Its breakdown leads to capillary leak and organ dysfunction. Moreover, sepsis-induced alterations of sublingual microcirculation are associated with a worse clinical …
Microcirculatory alterations in critically ill COVID-19 patients ...
2022年10月14日 · Background The sublingual microcirculation presumably exhibits disease-specific changes in function and morphology. Algorithm-based quantification of functional microcirculatory hemodynamic variables in handheld vital microscopy (HVM) has recently allowed identification of hemodynamic alterations in the microcirculation associated with COVID-19. In …