Nitric oxide signaling in health and disease - PubMed
2022年8月4日 · The surprising discovery that the diatomic gas nitric oxide (NO) is generated by mammalian cells and serves to regulate a multitude of physiological processes has continued to fascinate biologists for almost four decades. The biochemistry of NO is complex, and novel insights into the control of NO b …
Nitric Oxide: Physiological Functions, Delivery, and Biomedical ...
Nitric oxide (NO) is a gaseous molecule that has a central role in signaling pathways involved in numerous physiological processes (e.g., vasodilation, neurotransmission, inflammation, apoptosis, and tumor growth).
Nitric Oxide as a Unique Bioactive Signaling Messenger in …
Nitric oxide (NO) is an intra- and extracellular messenger that mediates diverse signaling pathways in target cells and is known to play an important role in many physiological processes including neuronal signaling, immune response, inflammatory response, modulation of ion channels, phagocytic defense mechanism, penile erection, and ...
Nitric oxide signaling - Abcam
2023年8月31日 · Explore nitric oxide signaling pathways in phagocytes (via iNOS), endothelial cells, and cardiomyocytes. Introduction to nitric oxide signaling. Nitric oxide (NO) is an essential molecule involved in several physiological and pathological …
Nitric oxide signaling in health and disease - Cell Press
In this review, we discuss the basics of NO biology and highlight recent advances and controversies in our understanding of the molecular mechanisms that govern NO signaling in health and disease, expanding the scope to include novel therapeutic opportunities.
Nitric Oxide Signaling and Regulation in the Cardiovascular …
2024年10月16日 · SIGNIFICANCE STATEMENT: After four decades of intensive research, questions persist about the transduction and control of nitric oxide (NO) synthase bioactivity. Here we discuss NO signaling in cardiovascular health and disease, highlighting new findings, such as the important role of red blood cells in cardiovascular NO homeostasis.
Nitric Oxide: A Regulator of Cellular Function in Health and Disease
How controlled S-nitrosylation/nitrotyrosination of proteins and activation of the NO/cGMP signalling pathway promote cellular survival and induce epigenetic changes while uncontrolled signalling promotes cell death and dysfunction remains to be elucidated.
Review Nitric oxide signaling in health and disease
2022年8月4日 · In this review, we discuss the basics of NO biology and highlight recent advances and controversies in our understanding of the molecular mechanisms that govern NO signaling in health and disease, expanding the scope to include novel therapeutic opportunities.
In this review, we discuss the basics of NO biology and highlight recent advances and controversies in our understanding of the molecular mecha-nisms that govern NO signaling in health and disease, expanding the scope to include novel therapeutic opportunities.
Nitric oxide signalling in cardiovascular health and disease
2018年2月1日 · In this Review, we summarize the updated paradigms on NOS regulation, NO interaction with reactive oxidant species in specific subcellular compartments, and downstream effects of NO in target...