Soluble Oligomer Assay Rivals Other Biomarkers in Detecting
2022年12月22日 · SOBA detected Aβ42 oligomers among controls who later developed mild cognitive impairment, suggesting it could identify people in the preclinical stage of AD. A …
Aβ Oligomers Purified from Human Brain | ALZFORUM
2016年5月6日 · The purification and characterization of Aβ oligomers from human brains by David Brody and colleagues reported here is an exciting and promising breakthrough in light of the …
CAPturing Oligomers from Biofluids | ALZFORUM
2022年7月7日 · Rodrigues and colleagues based their method on the structure of oligomers rather than their sequence, believing it would capture a range of oligomer species associated …
Aβ Oligomers and NMDA Receptors—One Target, Two Toxicities
2007年3月15日 · They found that the oligomers elicited a rapid increase in Ca2+, which could be prevented by memantine or the NR1 antibody. At first blush these two reports may seem to be …
Aβ Oligomers—Small Steps in Detection, Characterization
A research team led by Lee-Way Jin, University of California, Davis, report that Congo red and thioflavin T analogs can detect Aβ oligomers in living animals, while researchers at the …
Elusive or Not, Aβ Oligomers Are in BioPharma Crosshairs
The scientists claim this vaccine generates antibodies that bind oligomers and fibrils without causing ARIA. Verma and colleagues used dot blots to determine antigen specificity. They …
Stable Aβ Oligomers?—A Little Protein Engineering Goes a
2010年9月3日 · Oligomers of amyloid-β (Aβ) have created quite a stir since they were discovered to be perhaps the most toxic forms of the peptide. But oligomers are notoriously difficult to …
Two Classes of Aβ Oligomers Act Differently in the Brain
2015年6月22日 · In this model, type 2 oligomers again associated with plaques both temporally and spatially, but type 1 oligomers were absent at all ages. Because these mice express lower …
Think Oligomers Are Bad? Think Again.... | ALZFORUM
2011年10月26日 · One limitation of the approach is its reliance on SDS PAGE to detect the oligomers, suggested Sylvain Lesne of the University of Minnesota, Minneapolis. He pointed …
Oligomer Assay Finds Similar Aβ Profiles in AD and in Mice
2023年2月6日 · Busting Up Oligomers Knowing that Aβ oligomer profiles are similar in humans and mice, Willbold wondered if RD2, aka PRI-002 , a peptide that disrupts Aβ protofibrils and …