PD-1+CD8+ T Cell-Mediated Hepatocyte Pyroptosis Promotes
2024年11月4日 · The results identify a specific expanded pathogenic subset of PD-1 + CD8 + T cells in the liver, exhibiting strong functional activity and cytotoxicity against target cells. …
Nat. Immunol.｜效应细胞和调节性T细胞之间的PD-1表达平衡预测PD-1 …
2021年2月26日 · 本文说明肿瘤微环境中PD-1 + CD8 + T细胞相对于PD-1 + 调节性T 细胞（T reg ）的频率可预测程序性细胞死亡蛋白1（PD-1）阻断治疗的临床疗效，并且优于其他预测因 …
PD-1 maintains CD8 T cell tolerance towards cutaneous neoantigens
2023年6月21日 · In this setting, PD-1 enabled the maintenance of skin tolerance by preventing tissue-infiltrating antigen-specific effector CD8 T cells from (1) acquiring a fully functional, …
PD-1 status in CD8+ T cells associates with survival and anti-PD-1 …
2024年11月8日 · In a murine HPV + HNC model, anti-PD-1 mAb therapy differentially modulated PD-1 high/low populations, and tumor rejection associated with loss of dysfunctional PD-1 …
Anti-PD-1 cis-delivery of low-affinity IL-12 activates intratumoral CD8
2024年6月3日 · The αPD-1 antibodies effectively bind to intratumoral PD-1 + CD8 + T cells and directly anchor IL-12 on these effector cells. Our αPD1-mIL12mut2 fusion protein can induce …
Proliferation of PD-1+ CD8 T cells in peripheral blood after PD-1 ...
In this study, we analyzed longitudinal blood samples from advanced stage non–small cell lung cancer (NSCLC) patients (n = 29) receiving PD-1–targeted therapies. We detected an …
PD-1 blockade in subprimed CD8 cells induces dysfunctional PD-1 - Nature
2019年7月29日 · We show that PD-1 blockade in suboptimally primed CD8 + T cell conditions results in the generation of dysfunctional PD-1 + CD38 hi CD8 + cells 18, leading to resistance …
Rescue of exhausted CD8 T cells by PD-1–targeted therapies ... - Science
2017年3月31日 · Proliferation of PD-1 + CD8 T cells after blockade of the PD-1 pathway during chronic LCMV infection is contingent on CD28 expression. To examine whether CD28 …
LAG-3 and PD-1 synergize on CD8 - Cell Press
2024年8月8日 · PD-1- and LAG-3-deficient CD8 + T cells were transcriptionally distinct, with broad TCR clonality and enrichment of effector-like and interferon-responsive genes, resulting …
PD‐1+CD8+ T Cell‐Mediated Hepatocyte Pyroptosis Promotes …
2024年11月4日 · In vitro experiments reveal that PD-1 + CD8 + T cells can induce the pyroptosis of hepatocytes through elevated production of granzyme B and perforin-1. These results …
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