GPX4 in cell death, autophagy, and disease - PubMed
Selenoprotein GPX4 (glutathione peroxidase 4), originally known as PHGPX (phospholipid hydroperoxide glutathione peroxidase), is the main oxidoreductase in the use of glutathione as a reducing agent in scavenging lipid peroxidation products.
Biological significance of phospholipid hydroperoxide glutathione ...
2003年1月15日 · Phospholipid hydroperoxide glutathione peroxidase (PHGPx, GPx4) is a unique antioxidant enzyme that can directly reduce phospholipid hydroperoxide in mammalian cells. This contrasts with most antioxidant enzymes, which cannot reduce intracellular phospholipid hydroperoxides directly.
Phospholipid-hydroperoxide glutathione peroxidase - Wikipedia
In enzymology, a phospholipid-hydroperoxide glutathione peroxidase (EC 1.11.1.12) is an enzyme that catalyzes the chemical reaction 2 glutathione + a lipid hydroperoxide ⇌ {\displaystyle \rightleftharpoons } glutathione disulfide + lipid + 2 H 2 O
Involvement of GPx4-Regulated Lipid Peroxidation in Idiopathic ...
2019年10月15日 · Among GPx isoforms, GPx4 is a unique antioxidant enzyme that can directly reduce phospholipid hydroperoxide. Increased lipid peroxidation products have been demonstrated in IPF lungs, suggesting the participation of imbalanced lipid peroxidation in IPF pathogenesis, which can be modulated by GPx4.
Phospholipid Hydroperoxide Glutathione Peroxidase - an …
Phospholipid Hydroperoxide Glutathione Peroxidase (Gpx4) is a protein that protects against lipid peroxidation by reducing fatty acid hydroperoxides in phospholipids. It plays a crucial role in embryonal development, spermatogenesis, and defense against oxidative stress.
Glutathione peroxidase 4 overexpression inhibits ROS-induced …
2018年2月20日 · Glutathione peroxidase (GPX) is an intracellular antioxidant enzyme responsible for reducing peroxidized phospholipids. The GPX family member GPX4, also known as phospholipid-hydroperoxide...
A white paper on Phospholipid Hydroperoxide Glutathione …
2022年8月1日 · GPx4 is the vital selenoperoxidase active on membrane lipid hydroperoxides. The redox center is flanked by a site for binding the phospholipid polar head. GPx4 prevents regulated cell death routines operated by peroxidation. Survival controlled by GPx4 impacts on immunity inflammation and differentiation.
Elevated phospholipid hydroperoxide glutathione peroxidase …
2023年6月1日 · Phospholipid hydroperoxide glutathione peroxidase 4 (GPX4) is an intracellular antioxidant enzyme, that can directly reduce phospholipid, fatty acid, and cholesterol hydroperoxides [19, 28]. We previously reported that GPX4 overexpression reduces denervation-induced muscle loss [12].
Phospholipid Hydroperoxide Glutathione Peroxidase Induces a …
Phospholipid hydroperoxide glutathione peroxidase (PhGPx) is an antioxidant enzyme that reduces cellular phospholipid hydroperoxides (PLOOHs) to alcohols. Cellular peroxide tone has been implicated in cell growth and differentiation.
<br>磷脂氢过氧化物谷胱甘肽过氧化物酶 (GPX4 ... - X-MOL
Phospholipid hydroperoxide glutathione peroxidase 4 (GPX4) is an essential antioxidant enzyme that directly reduces phospholipid hydroperoxides and we previously reported that denervation-induced muscle atrophy is blunted in a mouse model of GPX4 overexpression.
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