Purinergic signalling - Wikipedia
Purinergic signalling (or signaling: see American and British English differences) is a form of extracellular signalling mediated by purine nucleotides and nucleosides such as adenosine and ATP. It involves the activation of purinergic receptors in the cell and/or in nearby cells, thereby regulating cellular functions. [1]
From purines to purinergic signalling: molecular functions and …
2021年4月28日 · Pathological deregulation of purinergic signalling contributes to various diseases including neurodegeneration, rheumatic immune diseases, inflammation, and cancer. Particularly, gout is one of...
Home | Purinergic Signalling - Springer
There is both short-term purinergic signalling in transmission and secretion and long-term (trophic) signalling in controlling cell proliferation, differentiation, motility and death in development and regeneration.
Comprehensive insights into potential roles of purinergic P2 …
2024年3月31日 · Purinergic receptors activated by purines and their derivatives represent a critical pathway in response to extracellular purine signaling. Based on the differences in endogenous ligands, purinergic receptors are categorized into two groups: purinergic P1 receptors and purinergic P2 receptors [3], [4].
Purinergic signaling: a common pathway for neural and …
2015年6月2日 · In this review we will analyze how purinergic signaling behaves as a common paracrine pathway that activates MSCs and neural stem cells (NSCs) in both physiological and pathological conditions. Neural progenitor cells in adult …
Purinergic regulation of the immune system - Nature
2016年2月29日 · Activation of purinergic signalling pathways can have both pro- and anti-inflammatory effects. During the acute stages of tissue injury, purinergic signalling can promote the recruitment and...
From purines to purinergic signalling: molecular functions and …
2021年4月28日 · Purinergic signalling is cross-linked with other transmitter networks to coordinate numerous aspects of cell behaviour such as proliferation, differentiation, migration, apoptosis and other physiological processes critical for the proper function of organisms.
Purinergic modulation of the immune response to infections
During inflammatory conditions, the purinergic signaling pathways are activated to initiate immune cell chemotaxis toward inflamed tissue and fine-tuned control local inflammation.
Purinergic Signalling in Physiology and Pathophysiology - PMC
Since its inception by the late Geoffrey Burnstock in the early 1970s [1], the concept of purinergic signalling has grown to encompass a complex network of cell-surface and intracellular organelle P2X, P2Y and P1 (adenosine) receptors, activated by extracellular nucleotides, particularly adenosine 5′-triphosphate (ATP), and adenosine, and variou...
Purinergic Signalling in Physiology and Pathophysiology - MDPI
2023年5月24日 · Since its inception by the late Geoffrey Burnstock in the early 1970s [1], the concept of purinergic signalling has grown to encompass a complex network of cell-surface and intracellular organelle P2X, P2Y and P1 (adenosine) receptors, activated by extracellular nucleotides, particularly adenosine 5′-triphosphate (ATP), and adenosine, and variou...