Alcohol Reactions: Williamson Synthesis using NaH, RX, and ROH
The Williamson Synthesis is an SN2 reaction that involves treating an alcohol with a strong base, such as sodium hydride (NaH) to form an alkoxy ion. Then, the alkoxy ion is reacted with an alkyl halide (RX) and an ether is formed:
17.6: Reactions of Alcohols - Chemistry LibreTexts
Alcohols react with the strongly acidic hydrogen halides HCl, HBr, and HI, but they do not react with nonacidic NaCl, NaBr, or NaI. Primary and secondary alcohols can be converted to alkyl chlorides and bromides by allowing them to react with a …
The Williamson Ether Synthesis – Master Organic Chemistry
2014年10月24日 · In the Williamson Ether Synthesis, an alkyl halide(or sulfonate, such as a tosylate or mesylate) undergoes nucleophilic substitution (SN2) by an alkoxide to give an ether. Being an S N 2 reaction, best results are obtained with primary alkylhalides or methyl halides. Tertiary alkyl halides give elimination instead of ethers.
17.6 Reactions of Alcohols - Chemistry LibreTexts
Alcohols react with the strongly acidic hydrogen halides HCl, HBr, and HI, but they do not react with nonacidic NaCl, NaBr, or NaI. Primary and secondary alcohols can be converted to alkyl chlorides and bromides by allowing them to react with a …
Alcohols - Organic Chemistry Tutor
You would typically use sodium hydride (NaH) as a base in this reaction to deprotonate your alcohol for two reasons. Firstly, NaH is a very strong base (probably one of THE strongest you’re going to encounter in your course) and it has no problems deprotonating an alcohol. Secondly, the side product in this reaction is H 2 gas, which makes it ...
The Reaction Between Alcohols and Sodium - Chemistry …
2023年1月23日 · We will look at the reaction between sodium and ethanol as being typical, but you could substitute any other alcohol and the reaction would be the same. If a small piece of sodium is dropped into ethanol, it reacts steadily to give off bubbles of hydrogen gas and leaves a colorless solution of sodium ethoxide: CH3CH2ONa C H 3 C H 2 O N a.
Primary and secondary alcohols are easily oxidized by a variety of reagents. The most common reagent used for oxidation of secondary alcohols to ketones is chromic acid, H2CrO4. Chromic acid is produced in situ by reaction of sodium dichromate, sulfuric acid and water.
Alcohols and Ethers - Louisiana Tech University
A. Alcohols react with alkali metals, sodium hydride (NaH), or sodium amide (NaNH 2) to produce alkoxide ions. Phenols react with sodium hydroxide to give the phenoxide ion. Alkoxides and phenoxides are strong bases and are used as reagents.
Reactions of Alcohols - Michigan State University
Shown below is a list of 16 different reagents and reaction conditions which, if selected and used in an appropriate manner, will produce the conversions shown in the diagram. 1. Na or NaH in an ether solvent. 2. Dilute aqueous acid (H 3 O +). 3. Reaction with a …
Alcohol Reactions Roadmap (PDF) - Master Organic Chemistry
2015年7月27日 · Let's summarize the key reactions of alcohols with this big reaction map [PDF] covering 67 reactions of alcohols, alkyl halides, alkenes, alkynes & more.