Less, but better: A simplified design for T cell redirection and ...
2022年12月12日 · In this issue of Cancer Cell, Smole et al. introduce a modular single vector system to simultaneously redirect T cell specificity toward cancer antigens while achieving activation-gated delivery of customizable payloads.
Covalent TCR-peptide-MHC interactions induce T cell activation …
2022年8月23日 · By studying T cells expressing natural or engineered TCRs, here we describe covalent TCR-pMHC interactions that involve a cysteine-cysteine disulfide bond between the TCR and the peptide.
T-Switch: A specificity-based engineering platform for developing …
2024年12月3日 · T cells play critical roles in cellular immunity, including the elimination of cancer cells with tumor-associated antigens. T cell receptors ... This serves as the first example of applying the T-Switch platform to redirect a TCR recognizing a bait antigen toward recognition of an endogenously processed and presented self-antigen.
Microenvironment-responsive anti-PD-L1 × CD3 bispecific T-cell …
2023年2月1日 · Bispecific T-cell Engager (BiTE) antibodies can redirect T-cells to tumor cells, and turn on the targeted lysis of tumor cells. However, BiTE has been challenging in solid tumors due to short plasma half-life, “off-target” effect, and immunosuppression via PD-1/PD-L1 axis.
Universal redirection of CAR T cells against solid tumours via
2023年6月8日 · In this Article, we report a strategy to employ amph-ligands as a means to redirect CAR T cells against any solid tumour.
Generation of T-cell-redirecting bispecific antibodies with ... - Nature
2021年7月13日 · T-cell-redirecting bispecific antibodies have emerged as a new class of therapeutic agents designed to simultaneously bind to T cells via CD3 and to tumor cells via tumor-cell-specific...
Frontiers | TCR Redirected T Cells for Cancer Treatment: …
Adoptive T cell therapy for cancer (ACT) is a branch of cancer immunotherapy that relies on the ability to redirect T cell specificity to selectively target tumor antigens.
T Cell Receptor-Directed Bispecific T Cell Engager Targeting MHC …
2024年4月1日 · Antibody-based bispecific T cell engagers (TCEs) that redirect T cells to kill tumor cells have shown a promising therapeutic effect on hematologic malignancies. However, tumor-specific targeting is still a challenge for TCEs, impeding the development of …
Direct in vivo CAR T cell engineering - ScienceDirect
2024年5月1日 · T cells modified to express intelligently designed chimeric antigen receptors (CARs) are exceptionally powerful therapeutic agents for relapsed and refractory blood cancers and have the potential to revolutionize therapy for many other diseases.
T Cell-Redirecting Strategies to ‘STAb’ Tumors: Beyond ... - Cell …
The redirection of T cell activity towards cancer cells via targeting of tumor-associated antigens (TAAs) by soluble bispecific antibodies (bsAbs) or membrane-anchored chimeric antigen receptors is one of the most promising cancer immunotherapy …