Regulatory B cell - Wikipedia
Regulatory B cells (Bregs or B reg cells) represent a small population of B cells that participates in immunomodulation and in the suppression of immune responses.
Regulatory B cells: origin, phenotype, and function - PubMed
2015年4月21日 · Regulatory B (Breg) cells are immunosuppressive cells that support immunological tolerance. Through the production of interleukin-10 (IL-10), IL-35, and transforming growth factor β (TGF-β), Breg cells suppress immunopathology by prohibiting the expansion of pathogenic T cells and other pro-inflamma …
Regulatory B Cells: Origin, Phenotype, and Function
2015年4月21日 · Regulatory B (Breg) cells are immunosuppressive cells that support immunological tolerance. Through the production of interleukin-10 (IL-10), IL-35, and transforming growth factor β (TGF-β), Breg cells suppress immunopathology by prohibiting the expansion of pathogenic T cells and other pro-inflammatory lymphocytes.
Immunosuppressive Mechanisms of Regulatory B Cells
2021年4月29日 · Regulatory B cells (Bregs) is a term that encompasses all B cells that act to suppress immune responses. Bregs contribute to the maintenance of tolerance, limiting ongoing immune responses and reestablishing immune homeostasis.
Regulatory B cells, A to Z - PubMed
This review provides an overview of our current knowledge on regulatory B cells. We discuss different types of regulatory B cells, the mechanisms through which they exert their regulatory functions, factors that lead to induction of regulatory B cells and their role in the alteration of inflammatory responses in different diseases.
Regulatory functions of B cells and regulatory plasma cells
It discusses the phenotypes of the B cell subsets most competent to produce IL-10 in vitro and to exert suppressive functions in vivo upon adoptive transfer in recipient mice, the signals and transcription factors regulating IL-10 expression in B cells, and the recent identification of plasmocytes, including short-lived plasmablasts and long-liv...
B cell-reactive triad of B cells, follicular helper and regulatory T ...
2024年2月7日 · Unexpectedly, we find that follicular B cell-derived autoantigen, including cell surface molecules such as FcγRIIB, is a class of homeostatic autoantigen that can induce spontaneous germinal...
Regulatory B cells in cancer - PMC - National Center for …
Here, we elaborate broadly on the history of regulatory B cells in cancer and summarize recent studies that have established genetic models for the study of regulatory B cell function and their potential for therapeutic intervention in the setting of solid cancers.
Diversity of regulatory B cells: Markers and functions
2024年7月31日 · Regulatory B cells (Bregs) are a functionally distinct B-cell subset involved in the maintenance of homeostasis and inhibition of inflammation. Studies, from the last two decades, have increased our understanding of cellular and molecular mechanisms involved in their generation, function, and to a certain extent phenotype.
Regulatory B cells: the cutting edge of immune tolerance in …
2018年1月25日 · Here, we review the latest evidence regarding phenotypes, functions, and effectors of Bregs and discuss their diverse effects on kidney transplantation. Besides antigen presenting and antibody...