SIRT1, Resveratrol and More: Moving Closer to Anti-aging Elixir?
2008年7月8日 · In these mice, SIRT1 was overexpressed two- to fourfold in a variety of tissues including liver, brown fat, and muscle. This moderate overexpression of SIRT1 protected the mice from lipid-induced inflammation, glucose intolerance, and fatty liver (hepatic steatosis) inflicted by high-fat diet, the researchers report.
Brain-Specific Sirtuin Expression Delays Aging in Mice
2013年9月11日 · That suggests that Sirt1 specifically in the dorsomedial and lateral hypothalamus is important for the anti-aging effect. Imai speculates that this could help settle the controversy about the role of Sirt1 aging in mice as high Sirt1 expression throughout the body might suppress neural activity in the dorsomedial and lateral hypothalamus.
Mechanisms and Memory: The Choreography of CREB, the …
2010年7月16日 · In the SIRT1 KOs, higher expression of miRNA-134 inhibits CREB production, and ultimately leads to less BDNF in the brain. To nail down this mechanism, the authors showed that the presence of excess miRNA-134 in wild-type mice could abolish LTP and impair memory, and that knockdown of miRNA-134 in SIRT1 KO mice was sufficient to rescue LTP and ...
Sirtuin Inhibitor Boosts Cognition, Reduces Phospho-tau
2008年11月21日 · These data suggest that loss of SIRT1 occurs at relatively late stages of AD, Calon told ARF. The full paper is currently in press in the Journal of Neuropathology and Experimental Neurology. Based on the nicotinamide data in mice, LaFerla’s group is recruiting mild to moderate AD patients for a six-month clinical trial.
BPN14770 | ALZFORUM
BPN14770 antagonized the amnestic effect of the anti-nausea drug scopolamine, whereby two weeks’ dosing boosted hippocampal phospho-CREB and BDNF, markers of memory consolidation. A subsequent study implicated cAMP-PKA-SIRT1-Akt -Bcl-2/Bax signaling in BPN14770's anti-scopolamine effect in these mice (Zhang et al., 2018; Wang et al, 2020). In ...
Melatonin MT1 receptors regulate the Sirt1/Nrf2/Ho-1/Gpx4 …
Lv QK, Tao KX, Yao XY, Pang MZ, Cao BE, Liu CF, Wang F.Melatonin MT1 receptors regulate the Sirt1/Nrf2/Ho-1/Gpx4 pathway to prevent α-synuclein-induced ferroptosis in Parkinson's disease.
Semaglutide ameliorates cognition and glucose metabolism
2023年12月1日 · Semaglutide ameliorates cognition and glucose metabolism dysfunction in the 3xTg mouse model of Alzheimer's disease via the GLP-1R/SIRT1/GLUT4 pathway. Neuropharmacology. 2023 Dec 1;240:109716. Epub 2023 Sep 18 PubMed. Recommends. Please login to recommend the paper. Comments. No Available Comments. Make a …
A Novel PDE4D Inhibitor BPN14770 Reverses Scopolamine
Wang Y, Gao S, Zheng V, Chen L, Ma M, Shen S, Qu J, Zhang H, Gurney ME, O'Donnell JM, Xu Y.A Novel PDE4D Inhibitor BPN14770 Reverses Scopolamine-Induced Cognitive Deficits via cAMP/SIRT1/Akt/Bcl-2 Pathway.
Semaglutide - ALZFORUM
Semaglutide ameliorates cognition and glucose metabolism dysfunction in the 3xTg mouse model of Alzheimer's disease via the GLP-1R/SIRT1/GLUT4 pathway. Neuropharmacology. 2023 Dec 1;240:109716. Epub 2023 Sep 18 PubMed. Zhang Y, Tang C, He Y, Zhang Y, Li Q, Zhang T, Zhao B, Tong A, Zhong Q, Zhong Z.
Tau Timing: New Findings on Disease Progression, Clearance
2010年10月1日 · Using transfected cell cultures, conditional knockout mice, and various loss of function and gain of function mutants, the authors then showed that it is the sirtuin protein SIRT1 that deacetylates tau both in vitro and in vivo. SIRT1 and tau co-immunoprecipitate, suggesting that they directly interact.