STAT1-NFκB crosstalk triggered by interferon gamma regulates ...
The present study evaluated the role of STAT1-NFκB crosstalk triggered by IFN-γ regarding the regulation of NA-induced pineal glands' hormonal production. Moreover, IFN-γ treatment increased NA-induced Aanat transcription, in addition to the synthesis of N …
Transcriptional Synergism between NF-κB and STAT1
2005年1月1日 · This review focuses on the cross-talk between NF-κB and STAT1 in the regulation of inflammatory gene expression and the mechanisms involved in the regulation of transcriptional synergy between NF-κB and STAT1.
NF-κB in biology and targeted therapy: new insights and ... - Nature
2024年3月4日 · JAK-STAT3 can act as an upstream regulator of NF-κB, promoting NF-κB signal transduction, while STAT1 inhibits NF-κB-mediated tumor cell survival; (4) TAK1 promotes NF-κB transcriptional...
NF-κB and STAT1 control CXCL1 and CXCL2 gene transcription
2014年1月15日 · We conclude that IL-1β-mediated regulation of the CXCL1 and CXCL2 genes in pancreatic β-cells requires stimulus-induced changes in histone chemical modifications, recruitment of the NF-κB and STAT1 transcription factors to genomic regulatory sequences within the proximal gene promoters, and increases in phosphorylated forms of RNA polymerase II.
Acetylation of Stat1 modulates NF-κB activity - PMC
2006年2月2日 · Our results indicate that the acetylation of Stat1 functions as a molecular switch, which permits binding of Stat1 to NF-κB and thus reduces NF-κB signaling. This mechanism appears to be critical for the induction of cell death by pharmacological and physiological stimuli.
Transcriptional Synergism between NF-κB and STAT1
2005年1月1日 · The cross-talk between NF-κB and STAT1 is orchestrated by transcriptional coactivator CREB binding protein (CBP) and p300, which integrate distinct extracellular signals in the nucleus for gene expression in the context of control of immune responses.
Jak-STAT 信号传导调节炎症 NF-kB 靶基因激活 - X-MOL
2023年8月10日 · IFN-γ 通过蛋白酪氨酸激酶 JAK1/2 发出信号，激活转录因子 STAT1 并驱动干扰素刺激基因 (ISG) 的表达。 当受到 Toll 样受体 4 (TLR4) 配体 (LPS) 攻击时，IFN-γ 引发的巨噬细胞诱导经典和非经典 ISG 的快速表达和增强。 然而，单独的 IFN-γ 无法引发被认为是促炎 NF-kB 靶基因的非经典 ISG 的表达。 基于这一观察，我们假设任何炎症刺激都可以协同激活 IFN-γ 引发的巨噬细胞中的 NF-kB 靶基因。 与脂多糖一样，TLR2 配体 (PAM3) 协同诱导 NF-kB 靶基因 …
JAK-STAT信号通路全面梳理：信号传导、激活与调控、主要基因、 …
2024年6月28日 · STAT（Signal Transducers and Activators of Transcription）家族包括STAT1、STAT2、STAT3、STAT4、STAT5A、STAT5B和STAT6等成员。它们是JAK激酶激活后被磷酸化的转录因子，在细胞核内调控基因表达。 SOCS家族： SOCS（Suppressor of Cytokine Signaling）家族包括SOCS1、SOCS2、SOCS3、SOCS4、SOCS5和SOCS6 ...
Control of specificity and magnitude of NF-κB and STAT1 ... - PNAS
Here we report that PIASy, a member of the PIAS (for protein inhibitor of activated STAT) protein family, is a physiologically important transcriptional repressor of NF-κB and STAT1. Piasy deletion in dendritic cells resulted in enhanced expression of a subset of NF-κB and STAT1-dependent genes in response to LPS or IFN-γ treatment ...
The CCL5/CCR5/SHP2 axis sustains Stat1 phosphorylation and activates NF ...
2024年12月5日 · Mechanistic dissection of the role of the CCL5/CCR5 axis in prostate inflammation through activation of the NF-κB and Stat1 pathways. Since few studies have explored the mechanism by which the CCL5/CCR5 axis regulates the activation of the NF-kB and Stat1 pathways, we aimed to investigate the significance of this process.