Schematic model representing the mechanisms of PLIN1 and …
PLIN1 and PLIN 2 block the LD access to lipases, and only a low rate of lipolysis takes place. Under lipogenic stimuli or FA surplus (central panel), PLIN2, PLIN3, and PLIN4 localize on nascent...
Production of the C-terminal domain of Perilipin 1. (A) Schematic ...
Download scientific diagram | Production of the C-terminal domain of Perilipin 1. (A) Schematic representation of PLIN1, the number above box refers to the amino acid position. (B)...
Schematic representation of basal and stimulated lipolysis in …
Under basal conditions, perilipin 1 (PLIN1) binds α/β hydrolase domain containing protein 5 (ABHD5) and prevents the interaction of ABHD5 with adipose triglyceride lipase (ATGL), thereby ...
运动以Perilipins和FATP为靶点对脂滴代谢与UPR的调控作用
2023年2月27日 · plin1主要存在脂肪组织中，其主要功能是增加细胞内tag的积累并抑制脂解，进而增加脂滴的体积。 PLIN1在脂滴生成早期主要是和脂滴结合，并通过TAG的积累促进脂滴生物发生（Gao et al.， 2017）。
Perilipin1 promotes unilocular lipid droplet formation through the ...
2013年3月12日 · Here, we identify Perilipin1 (Plin1), another adipocyte-specific lipid droplet-associated protein, as an Fsp27 activator. Plin1 interacts with the CIDE-N domain of Fsp27 and markedly increases...
A suite of new Dre recombinase drivers markedly expands the …
2021年6月3日 · (A) Schematic diagram illustrating the generation of Plin1-dCreER by homologous recombination using CRISPR-Cas9. (B) Whole-mount bright-field and fluorescence images of intracapsular brown adipose tissue (BAT), inguinal white adipose tissue (ingWAT), and epididymal white adipose tissue (epiWAT) from adult Plin1-dCreER;R26-tdTomato mice treated ...
Lipid Droplets: Formation to Breakdown | Lipids - Springer
2017年5月20日 · Schematic diagram of a mature lipid droplet. Lipid droplet interiors contain neutral lipids. The neutral lipid content of whole-cell droplets varies among species and cell types. Certain cells such as adipocytes contain mostly TAG whereas foam cells contain mostly SE. The non-polar interior of a droplet is surrounded by a phospholipid monolayer.
A PLIN1 polymorphism is associated with fat production in male …
In this study, we investigated the relationship between production traits and perilipin 1-encoding gene (PLIN1) polymorphisms in the emus. We determined the partial complementary DNA (cDNA) sequence of the PLIN1, which is involved in lipid droplet formation.
Conserved Amphipathic Helices Mediate Lipid Droplet Targeting …
2016年3月25日 · PLIN1-(93–192) are sufficient to target lipid droplets when expressed in a GFP-tagged bioprobe. A, schematic diagram of the bioprobe consisting of the Golgi microtubule-associated protein coiled-coil domain separating the putative AHs and the GFP tag.
CIDE proteins and their regulatory mechanisms in lipid droplet …
2024年2月14日 · (C) Schematic diagram showing the mechanism of CIDE-mediated lipid droplet (LD) fusion and growth. Three regulators, namely CLSTN3β, Rab8a-GDP, and Plin1, interact with Cidea or Cidec and regulate the formation of CIDE-mediated fusion plate and lipid-permeable passageways and subsequent neutral lipid transfer.