Senescence (/ s ɪ ˈ n ɛ s ə n s /) or biological aging is the gradual deterioration of functional characteristics in living organisms. Whole organism senescence involves an increase in death rates or a decrease in fecundity with increasing age, …

Senescence is a cellular response characterized by a stable growth arrest and other phenotypic alterations that include a proinflammatory secretome. Senescence plays roles in normal development, maintains tissue homeostasis, and limits tumor progression. However, senescence has also been implicated as a major cause of age-related disease.

The meaning of SENESCENCE is the state of being old : the process of becoming old or aging. How to use senescence in a sentence. Did you know?

2021年7月13日 · Learn about cellular senescence, what it is and how NIA-funded research is exploring how understanding this process may contribute to healthy aging.

2020年12月16日 · Cellular senescence occurs in response to many different triggers, including DNA damage, telomere dysfunction, oncogene activation and organelle stress, and has been linked to processes such as...

2021年7月21日 · Senescence pertains to the biological aging of a living thing. It entails the gradual deterioration of morphological features and the function of a cell or of the whole organism. On the cellular level, senescence is that stage in a cell’s cycle wherein it ceases to divide.

Cellular senescence, a process that imposes permanent proliferative arrest on cells in response to various stressors, has emerged as a potentially important contributor to aging and age-related disease, and it is an attractive target for therapeutic exploitation.