Spectrin: structure, function and disease - PubMed
Spectrin is a large, cytoskeletal, and heterodimeric protein composed of modular structure of α and β subunits, it typically contains 106 contiguous amino acid sequence motifs called "spectrin repeats".
Spectrins: Current Biology - Cell Press
2021年5月24日 · Spectrins are ubiquitous cytoskeletal and scaffolding proteins found in all metazoan cells. They are primarily located at the inner cytoplasmic face of the plasma membrane where they interact with actin and a variety of scaffolding proteins that …
Spectrins: A structural platform for stabilization and activation …
2014年2月1日 · Spectrin is a platform for membrane channels, receptors and transporters. Spectrin contains domains which function as interfaces for receiving signals. This review focuses on structure and functions of spectrin as a major component of the membrane skeleton.
The role of spectrin in cell adhesion and cell–cell contact - PMC
In this mini-review, we focus on data concerning the role of spectrins in cell surface activities such as adhesion, cell–cell contact, and invadosome formation. We discuss data on different adhesion proteins that directly or indirectly interact with spectrin repeats.
Spectrin - an overview | ScienceDirect Topics
Spectrin is an abundant protein in the nervous system, comprising 2.4% of total protein in mammalian brain homogenates. Spectrin is an unusually large protein with a native molecular weight greater than 1 million. The contour length of the purified protein when viewed by electron microscopy is ∼200 nm. Spectrin is intimately associated with ...
Spectrin: Structure, function and disease | Science China
2013年12月5日 · Spectrin is a large, cytoskeletal, and heterodimeric protein composed of modular structure of α and β subunits, it typically contains 106 contiguous amino acid sequence motifs called “spectrin repeats”.
Spectrins: molecular organizers and targets of neurological
2023年1月25日 · Spectrins are cytoskeletal proteins that are expressed ubiquitously in the mammalian nervous system. Pathogenic variants in SPTAN1, SPTBN1, SPTBN2 and SPTBN4, four of the six genes encoding...
Spectrin-based skeleton as an actor in cell signaling - PMC
2011年8月30日 · We discuss new data concerning the commonly known role of the spectrin-based skeleton in control of membrane organization, stability and shape, and tethering protein mosaics to the cellular motors and to all major filament systems.
Cytoskeletal Integrators: The Spectrin Superfamily - PMC
This review discusses the spectrin superfamily of proteins that function to connect cytoskeletal elements to each other, the cell membrane, and the nucleus. The signature domain is the spectrin repeat, a 106–122-amino-acid segment comprising three ...
Spectrin is a mechanoresponsive protein shaping fusogenic synapse ...
2018年5月25日 · Spectrin is a membrane skeletal protein best known for its structural role in maintaining cell shape and protecting cells from mechanical damage.
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