A model about regulation on three division modes of stem cell
2024年3月21日 · We construct a multi-stage cell lineage model for cell division, apoptosis and movement. Cells are assumed to secrete and respond to negative feedback molecules which act as a control on the stem cell divisions (including self-renewal, asymmetrical cell division (ACD) and differentiation).
Stem cell homeostasis regulated by hierarchy and neutral
2022年11月18日 · Two distinct models have been proposed as mechanisms of stem cell homeostasis. According to the classical model, there is hierarchy among stem cells, and master stem cells produce...
Mechanisms of Asymmetric Stem Cell Division - Cell Press
2008年2月22日 · Below, I describe the anatomy and molecular machineries of asymmetric cell division in Drosophila neuroblasts and ovarian germline stem cells and use neural, muscle, and hematopoietic stem cells as examples to illustrate the similarities and differences in higher organisms (see Table 1 for a summary of the model systems described).
A cell model about symmetric and asymmetric stem cell division
2023年3月7日 · We construct a multi-stage cell lineage model including self-renewal, apoptosis, cell movement and the symmetrical/asymmetrical division of stem cells. The evolution of cell populations can be described by coupled reaction–diffusion partial differential equations, and the propagating wavefront speeds can be obtained analytically and verified ...
Asymmetric and symmetric stem-cell divisions in development
2006年6月28日 · Much has been made of the idea that asymmetric cell division is a defining characteristic of stem cells that enables them to simultaneously perpetuate themselves (self-renew)...
The recent advances in the mathematical modelling of human
2020年1月27日 · Human pluripotent stem cells (hPSCs) have the ability to self-renew indefinitely through repeated divisions (mitosis) and can differentiate into any bodily cell type (the pluripotency property). The latter property underpins their promising clinical applications in drug discovery, cell-based therapies and personalised medicine [1, 2].
Mathematical Models of Stem Cell Differentiation and ... - Springer
2019年4月13日 · To maintain and repair adult tissues, a balance must be maintained between stem cell proliferation and generation of differentiated offspring. This review explores recent mathematical and computational models that address stem cell fate decisions in adult tissues in the context of normal tissue regulation and cancer development.
Symmetric vs. Asymmetric Stem Cell Divisions: An Adaptation …
In the asymmetric division model, a stem cell produces one differentiated cell and one stem cell. In the symmetric division model, a stem cell produces two differentiated cells or two stem cells. Uncovering division patterns of stem cells has been subject …
Modes of division and differentiation of neural stem cells - PMC
Here, we describe current models of hippocampal stem cell maintenance and differentiation, and emphasize key features of neural stem cells’ turnover that may define hippocampal neurogenesis enhancement attempts’ long-term consequences.
Different models of stem cell division. In model A, each stem or ...
In model A, each stem or progenitor cell gives rise to a different cell type requiring a different stem cell population for each tissue. Models B and C demonstrate the possibility of...