Neuronal haemoglobin induces loss of dopaminergic neurons in mouse …
2022年12月16日 · Parkinson’s disease (PD) presents the selective loss of A9 dopaminergic (DA) neurons of Substantia Nigra pars compacta (SNpc) and the presence of intracellular aggregates called Lewy bodies....
On the properties of identified dopaminergic neurons in the mouse …
We studied the properties of dopaminergic neurons in the substantia nigra pars compacta (SNpc) and ventral tegmental area (VTA) in mice expressing the enhanced green fluorescent protein (eGFP) under the control of the tyrosine hydroxylase promoter (TH-GFP).
Morphological and functional alterations in the substantia nigra …
2011年2月1日 · The mDA area substantia nigra pars compacta (SNpc — A9) regulates the elaboration of motor strategies (Blandini et al., 2000). A dopaminergic deficit induces motor defects in primates and rodents, and Parkinson's disease in humans (Jenner, 2008).
Age-Mediated Transcriptomic Changes in Adult Mouse Substantia Nigra
2013年4月30日 · Substantia nigra pars compacta (SNpc) is highly sensitive to normal aging and selectively degenerates in Parkinson's disease (PD). Until now, molecular mechanisms behind SNpc aging have not been fully investigated using high throughput techniques.
Single-cell genomic profiling of human dopamine neurons …
2022年5月5日 · The loss of dopamine (DA) neurons within the substantia nigra pars compacta (SNpc) is a defining pathological hallmark of Parkinson’s disease (PD).
Single-cell analysis of gene expression in the substantia nigra …
2022年1月1日 · In this report, we evaluate the cellular and gene expression changes occurring in the SNpc in a mouse model of PD induced using MNPQ. We obtained a low yield of viable single cells from the SNpc and the data were of marginal quality, despite stringent filtering.
Characterization of substantia nigra neurogenesis in …
2021年6月10日 · BNN-20 is a synthetic, BDNF-mimicking, microneurotrophin that we previously showed to exhibit a pleiotropic neuroprotective effect on the dopaminergic neurons of the SNpc in the “weaver” mouse model of PD. Here, we assessed its potential effects on neurogenesis.
Neuroanatomy, Substantia Nigra - StatPearls - NCBI Bookshelf
2024年9月10日 · Located within the midbrain posterior to the crus cerebri fibers of the cerebral peduncle, the substantia nigra can be functionally and morphologically divided into 2 regions, the pars compacta (SNpc) containing dopaminergic neurons and the pars reticulata (SNpr) with inhibitor gamma-aminobutyric acid-containing (or GABAergic) neurons (see .
A comparison of model-based (2D) and design-based (3D) …
2009年7月21日 · In this study, we used serial sections to reconstruct the SNpc from C57BL/6J mouse brains and directly count the number of DA neurons present. We then compared this number to estimates determined using model-based and design-based stereology and found no significant statistical differences in cell number using all three methods.
Dopaminergic neurodegeneration in the substantia nigra is …
2023年10月21日 · In mice with intranasal ferric ammonium citrate administration, we observed olfactory dysfunction when dopaminergic neurodegeneration in substantia nigra occurred and was restored when ...
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