A guide to thymic selection of T cells - Nature
2023年7月18日 · This paper reports that bacterial antigens from the gut are presented in the thymus under some conditions. These surprising findings present a new paradigm for T cell development.
T-cell maturation, activation and differentiation
2020年7月30日 · T-cells development initiates with the arrival of small numbers of lymphoid precursors migrating from the blood into the thymus where they proliferate, differentiate and undergo selection process that result in the development of mature T cells.
T Cell (T Lymphocyte)- Definition, Types, Development, …
2022年4月10日 · T cells can be distinguished from other lymphocytes like B cells as the maturation and differentiation of T cells occurs in the thymus. There are different subsets of T cells that are involved in different functions of the cells. These cells are the primary reason for immune-mediated cell death.
T cells in health and disease | Signal Transduction and ... - Nature
2023年6月19日 · In this review, we summarize the current understanding of T cell development, CD4+ and CD8+ T cell classification, and differentiation in physiological settings.
20.3C: Maturation of T Cells - Medicine LibreTexts
T cells are produced in the bone marrow but travel to the thymus to mature. T cells can be either helper T cells or cytoxic T cells based on whether they express CD4 (helper) or CD8 ( cytotoxic ) glycoprotein.
Human T Cell Development, Localization, and Function …
2018年2月20日 · We will discuss these multiple aspects of human T cell responses, beginning with T cell development, the role of naive and regulatory T cells, differentiation to effector and memory subsets, and how tissue localization impacts T cell function and maintenance.
Key Factors for Thymic Function and Development - PMC
Thymocyte differentiation is regulated by direct contact with the stromal-epithelial microenvironment and responds to various cytokines produced by thymic stromal and lymphoid cells. IL-7, produced by TECs, is the key regulator of T cell maturation, differentiation, and survival in the early stages of their generation (37, 159). However, many ...
T-cell development and the CD4–CD8 lineage decision - Nature
2002年5月1日 · This study provides clear evidence that high MAPK activity favours the development of CD4 + single-positive T cells and low MAPK activity favours the development of CD8 + single-positive T...
In this review, we discuss how human T cells develop and provide essential immune protection at different life stages and highlight tissue localization and subset delineation as key determinants of the T cell functional role in im-mune responses.
Mechanisms of T cell development and transformation - PubMed
2020年7月1日 · T cell progenitors originate in the bone marrow and, through a series of defined and coordinated developmental stages, enter the thymus, differentiate, undergo selection, and eventually mature into functional T cells.