The TP53 Gene and Its Role in Cancer - Verywell Health
2023年10月25日 · What is TP53 and what role does it play in cancer? The TP53 gene is a gene that is mutated in many cancers. It is the most common gene mutation found in cancer cells. A …
TP53 gene - MedlinePlus
The TP53 gene provides instructions for making a protein called tumor protein p53 (or p53). This protein acts as a tumor suppressor, which means that it regulates cell division by keeping cells …
TP53 mutations in cancer: Molecular features and therapeutic ...
Mutations in the TP53 gene or functional inactivation of the p53 protein play a crucial role in cell transformation and the development of cancers. Missense nucleotide changes in the TP53 …
Tumor Suppressor p53: Biology, Signaling Pathways, and …
TP53 is a gene that encodes for the p53 tumor suppressor protein, commonly referred to as the “Guardian of the Genome” [1]. Its main biological function appears to involve the protection of …
TP53 Gene - GeneCards | P53 Protein | P53 Antibody
2024年10月2日 · p53 (TP53) is a transcription factor whose protein levels and post-translational modification state alter in response to cellular stress (e.g. hypoxia, DNA and spindle damage). …
The TP53 Database
The TP53 Database compiles various types of data and information from the literature and generalist databases on human TP53 gene variations related to cancer. The database is …
Targeting p53 pathways: mechanisms, structures and advances in …
2023年3月1日 · Here, we provide a systematic review of the diverse molecular mechanisms of the p53 signaling pathway and how TP53 mutations impact tumor progression. We also discuss …
TP53 tumor protein p53 [Homo sapiens (human)] - Gene - NCBI
2024年11月18日 · HIV-1 Vpu expression results in significant upregulation of phosphorylated p53. Vpu contributes to p53-dependent apoptosis in HIV-1-infected cells. HIV-1 IN-mediated …
Mutant p53 in cancer: from molecular mechanism to therapeutic ...
2022年11月18日 · TP53, a crucial tumor suppressor gene, is the most commonly mutated gene in human cancers. Aside from losing its tumor suppressor function, mutant p53 (mutp53) often …
Tumor suppressor p53: Biology, signaling pathways, and ... - PubMed
TP53 is the most commonly mutated gene in human cancer with over 100,000 literature citations in PubMed. This is a heavily studied pathway in cancer biology and oncology with a history …
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