In many species, the sequence repeats are enriched in guanine, e.g. TTAGGG in vertebrates, [15] which allows the formation of G-quadruplexes, a special conformation of DNA involving non-Watson-Crick base pairing. There are different subtypes depending on the involvement of single- or double-stranded DNA, among other things.

A highly conserved repetitive DNA sequence, (TTAGGG)n, has been isolated from a human recombinant repetitive DNA library. Quantitative hybridization to chromosomes sorted by flow cytometry indicates that comparable amounts of this sequence are …

Telomere-binding proteins (also known as TERF, TRBF, TRF) function to bind telomeric DNA in various species. In particular, telomere-binding protein refers to TTAGGG repeat binding factor-1 (TERF1) and TTAGGG repeat binding factor-2 (TERF2). [1] .

2014年1月6日 · The increasing interest in studying biomolecules under more cellular-like conditions prompted us to investigate the effect of osmotic stress on the structural and thermodynamic properties of DNA oligomers containing …

2024年6月1日 · The telomere sequence, TTAGGG, is conserved across all vertebrates and plays an essential role in suppressing the DNA damage response by binding a set of proteins termed shelterin. Changes in...

The conservation of the (TTAGGG)n sequence and its telomeric location, in species thought to share a common ancestor over 400 million years ago, strongly suggest that this sequence is the functional vertebrate telomere.

2011年3月22日 · The TTAGGG DNA repeat proteins 1 and 2 (TRF1 and TRF2) bind to mammalian telomeres as part of the shelterin complex and are essential for maintaining chromosome end stability.

TTAGGG is a repetitive DNA sequence known as a telomere repeat, which is found at the ends of linear chromosomes in eukaryotic cells. This sequence plays a crucial role in protecting chromosomes from degradation and preventing the loss of important genetic information during DNA replication.

(TTAGGG)., has been isolated from a human recombinant repetitive DNA library. Quantitative hybridization to chromo-somes sorted by flow cytometry indicates that comparable amounts of this sequence are present on each human chromo-some. Both fluorescent in situ hybridization and BAL-31 nuclease digestion experiments reveal major clusters of this

Telomeres (the TTAGGG repetitive DNA at the ends of linear chromosomes) are part of the 3D spatial organization of the nuclear genome. Long-range 3D chromatin interactions also establish specific patterns of regulated gene expression.