Replication kinetics of turkey herpesvirus in lymphoid organs …
2021年9月2日 · To understand the lifecycle of HVT in inoculated chickens via the subcutaneous route, we investigate the replication kinetics and tissue organ tropism of HVT in chickens by a subcutaneous inoculation which is a major route of MDV vaccination.
Evaluation of Tissue Tropism and Horizontal Transmission of a …
2024年10月29日 · This review describes the construction and characterization of primarily poultry vaccine vectors, including fowl poxvirus (FPV), fowl adenovirus (FAdV), Newcastle disease virus (NDV), Marek’s disease virus (MDV), Marek’s disease virus …
Evaluation of Tissue Tropism and Horizontal Transmission of a …
2024年10月29日 · In this work, tissue affinity and horizontal transmission in 1-day-old chickens were systematically evaluated after DEV-H5 vector vaccine inoculation. Sixty percent of DEV-H5-inoculated chickens died between day 2 and day 7 post-inoculation. The displayed clinical signs consisted of lethargy, anorexia, and diarrhea, and virus was shed in feces.
The Genome of Turkey Herpesvirus - PMC - PubMed Central (PMC)
Significant genomic differences occur between HVT and MDV1 in and adjacent to RL and RS, and these may account for differences in tissue tropism, host range, and the nonpathogenic phenotype of HVT . HVT lacks putative MDV1 virulence and host range genes, including MEQ, pp24, pp38, CxC chemokine, MDV087 (SORF2), and MDV093 (SORF4).
Evaluation of Tissue Tropism and Horizontal Transmission of a …
Herpesvirus of turkey (HVT) recombinant vector vaccines are widely used in the poultry industry. However, due to limitations in loading multiple foreign antigens into a single HVT vector, other viral vectors are urgently needed. Since chickens lack ...
Viral Tropism - an overview | ScienceDirect Topics
Viral tropism refers to the capability of an infectious virus to infect particular cells (cellular tropism), tissue (tissue tropism) or host species (host tropism). 64 Not all types of virus can infect humans. To understand the characteristics of a particular infectious virus and its impact on humans, the first important aspect is to know the ...
Translational adaptation of human viruses to the tissues they infect
2021年3月3日 · Overall, we observe a tropism-specific adaptation of the viral proteome to the tRNA profiles of their target tissues, which opens the door for the development of tissue-specific codon-deoptimized vaccines and targeted antiviral therapies.
investigate the replication kinetics and tissue organ tropism of HVT in chickens by a subcutaneous inoculation which is a major route of MDV vaccination. We show that the progeny virus matured
9.5C: Tissue Tropism in Animal Viruses - Biology LibreTexts
2024年11月23日 · An example of this is the HIV virus, which exhibits tropism for CD4 related immune cells (e.g. T helper cells, macrophages or dendritic cells). These cells express a CD4 receptor, to which the HIV virus can bind, through the gp120 and gp41 proteins on its surface.
Spatial transcriptomics for profiling the tropism of viral ... - Nature
2023年1月26日 · In this study, we developed an ultrasensitive, sequential fluorescence in situ hybridization (USeqFISH) method for spatial transcriptomic profiling of endogenous and viral RNA with a short barcode...