IFNγ guides the suppressive activity of Treg cells during viral ...
2023年4月7日 · We now show that T H 1-like T reg cells enhance the suppression of virus-specific T cells, which provides a foundational mechanism by which T H 1-like T reg cells might contribute to, or be...
How regulatory T cells work | Nature Reviews Immunology
Regulatory T (T Reg) cells are essential for maintaining peripheral tolerance, preventing autoimmunity and limiting chronic inflammatory diseases. However, they also limit beneficial...
IFNγ-induction of TH1-like regulatory T cells controls antiviral ...
2023年3月16日 · These findings provide fundamental insights into how Treg cells sense inflammatory cues from the environment (such as IFNγ) during viral infection to provide guidance to the effector immune...
Principles of regulatory T cell function: Immunity - Cell Press
2023年2月14日 · Treg cells are an immunosuppressive lymphocyte subset essential for preventing autoimmunity. Dikiy and Rudensky review the mechanisms by which Treg cells prevent autoimmunity, mitigate inflammation, and support tissue function.
The Complex Role of Regulatory T Cells in Immunity and Aging
Low responsiveness and reduced proliferation of virus-specific T cells during chronic viral infection is associated with the expansion of Treg. In acute and chronic murine retroviral infection models, depletion of Treg decreases viral load and restores the activity of virus-specific cytotoxic CD8 + …
Beneficial and Detrimental Effects of Regulatory T Cells in …
2020年3月2日 · Regulatory T cells (Treg) play a critical role for immune homeostasis, but may inhibit pathogen-specific immunity in infectious disorders. The present review summarizes the current knowledge about Treg in human CNS infections and their animal models.
PD-1 upregulated on regulatory T cells during chronic virus ... - PubMed
2015年6月15日 · Regulatory T (Treg) cells act as terminators of T cell immuniy during acute phase of viral infection; however, their role and suppressive mechanism in chronic viral infection are not completely understood. In this study, we compared the phenotype and function of Treg cells during acute or chronic infection with lymphocytic choriomeningitis virus.
PD-1 Upregulated on Regulatory T Cells during Chronic Virus …
2015年6月15日 · In this study, we compared the phenotype and function of T reg cells during acute or chronic infection with lymphocytic choriomeningitis virus. Chronic infection, unlike acute infection, led to a large expansion of T reg cells and their upregulation of …
Regulatory T-cell expansion during chronic viral infection is ... - PNAS
2011年1月10日 · Regulatory T cells (Treg) play critical roles in the modulation of immune responses to infectious agents. Further understanding of the factors that control Treg activation and expansion in response to pathogens is needed to manipulate Treg function in acute and chronic infections.
JCI - Differential roles of regulatory T cells in acute respiratory ...
2023年7月17日 · CD4 + FOXP3 + regulatory T cells (Tregs) interact with cells of both the innate and the adaptive immune system to limit acute pulmonary inflammation and promote its resolution. Tregs also provide tissue protection and coordinate lung tissue repair, facilitating a return to homeostatic pulmonary function.
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