Function and Role of Regulatory T Cells in Rheumatoid Arthritis
The loss or functional deficiency of key immune cells, regulatory T (Treg) cells, has been confirmed in human autoimmune diseases. The pathogenesis of RA is complex, and the dysfunction of Tregs is one of the proposed mechanisms underlying the breakdown of self-tolerance leading to the progression of RA.
Exploring the therapeutic potential of regulatory T cell in rheumatoid …
2024年5月1日 · In this review, we summarize the latest advances in understandings of Tregs in RA and highlight the impact of their surface markers, inhibitory mechanism, and signaling pathways aiming to investigate the role of Tregs-mediated immune tolerance in RA and discuss novel treatment strategies for RA based on Treg biology, thereby offering potential ...
Regulatory T cells in rheumatoid arthritis: functions, …
In this review, we summarize and discuss the current knowledge about the function, differentiation and regulation of Treg cells in RA patients and in animal models of autoimmune arthritis. In addition, we highlight the therapeutic potential as well as the challenges of Treg cell targeting treatment strategies.
The Role of Different Subsets of Regulatory T Cells in ...
2012年10月24日 · Identification of regulatory T cells (Tregs) led to breaking the dichotomy of Th1/Th2 responses in several pathogenic and autoimmune conditions. It is shown that Th1 cells have the deleterious function in immunopathogenesis of several autoimmune diseases, whereas Th2 cells exert favorable responses [ 1 , 2 ].
Interleukin-2 and regulatory T cells in rheumatic diseases
2021年11月2日 · In this Review, Kolios, Tsokos and Klatzmann provide an overview of Treg cell and IL-2 involvement in rheumatic diseases and how modulating IL-2 signalling and Treg cell biology might provide...
Treg cells in rheumatoid arthritis: an update - PubMed
This review addresses recent findings in the field of Tregs in RA, with particular focus on identification of potential defects in Treg-mediated self-tolerance mechanisms present in RA patients, as well as how Tregs interact with other cells in the inflamed joints.
Th17/Treg-Related Transcriptional Factor Expression and Cytokine ...
2020年12月11日 · Our study aimed to determine whether there is a correlation between expression of transcription factors and Th17/Treg ratio, cytokine profile in the RA phenotype as well as to identify transcription factors that could be potential diagnostic biomarkers for RA.
Regulatory T cells (Treg) in rheumatoid arthritis - ScienceDirect
2009年1月1日 · Modulation of the T-cell response depends chiefly on regulatory T cells (Treg), which express CD4 and CD25. Some Treg cells are present naturally, whereas others are induced in response to antigens. The immunomodulating effects of Treg cells are mediated by membrane molecules (e.g., CTLA4, GITR, and OX40) and cytokines.
Protectin DX restores Treg/Th17 cell balance in rheumatoid
2021年3月15日 · Our study explored the protective effect of protectin DX (PDX), which restored Treg/T h 17 cell balance in RA, and the role of the nucleotide-binding domain (NOD)–like receptor protein 3 (NLRP3)...
Review Th17 and regulatory T cell balance in autoimmune and ...
2014年6月1日 · Inhibition of inflammatory cytokines regulates the Th17/Treg balance. This review focuses on the biology of T helper 17 (Th17) and regulatory T (Treg) cells and their role in inflammatory diseases, such as rheumatoid arthritis. Th17 cells represent a pro-inflammatory subset whereas Treg cells have an antagonist effect.