A trifluoromethyl group is defined as a substituent in organic chemistry with unique stereoelectronic properties, characterized by high electronegativity and close Van-der-Waals radii. It plays a crucial role in drug-receptor interactions by increasing lipophilicity and improving transport characteristics of bioactive molecules.

2022年10月11日 · Among them, most of the compounds were found to have fluorine or fluorine-containing functional groups exhibiting numerous pharmacological activities. Herein, we summarized the trifluoromethyl (TFM, -CF3)-group-containing FDA …

2015年8月10日 · Here we report a strategy for the use of trifluoroacetic anhydride for a scalable and operationally simple trifluoromethylation reaction using pyridine N -oxide and photoredox catalysis to...

The trifluoromethyl group, represented as -CF3, is a highly electronegative and hydrophobic functional group commonly found in organic compounds. It is an important structural feature that can significantly impact the physical, chemical, and biological properties of molecules.

2014年11月1日 · Drawing inspiration from this prospect, we have designed the present review article providing a brief outline of the recent advances in the trifluoromethylation methodology in connection with some CF 3 -containing drug candidates currently under the development by the pharmaceutical industries.

2021年4月23日 · The trifluoromethyl group plays an increasingly important role in pharmaceuticals, agrochemicals and materials. This tutorial describes recent advances in trifluoromethylation of carbon-centered radical intermediates.

trifluoromethyl carbinols: trifluoromethyl alkenes: β-trifluoromethyl alcohols: trifluoromethyl allenes: trifluoromethyl ketones: trifluoromethyl alkynes: α-trifluoromethyl carbonyl compounds: benzylic trifluoromethanes: α-trifluoromethyl carboxyl derivatives: allylic trifluoromethanes: α-trifluoromethyl amines: propargylic ...

Trifluoromethylation is described as the process of introduction of a trifluoromethyl group into an organic compound [8]. From: Journal of Organometallic Chemistry, 2022

2016年9月16日 · The trifluoromethyl group has become an important structural component of many bioactive compounds, mainly because of its polar influence and its effect on the lipophilicity of compounds. This chapter gives a few illustrative examples of important agrochemicals and pharmaceuticals that contain a CF 3 group are given as follows.

2017年4月5日 · MP2/aug-cc-pVDZ calculations on model systems demonstrate the effect of the unusual group polarizability of trifluoromethyl. A survey of the Protein Databank reveals more than 600 weak interactions involving a trifluorotoluene moiety.