Expression, Regulation, and Function of IGF-1, IGF-1R, and IGF …
2003年11月6日 · The vascular insulin-like growth factor (IGF)-1 system includes the IGFs, the IGF-1 receptor (IGF-1R), and multiple binding proteins. This growth factor system exerts …
Regulation of vascular endothelial growth factor-dependent retinal ...
Here we show that an IGF-1 receptor antagonist suppresses retinal neovascularization in vivo, and infer that interactions between IGF-1 and the IGF-1 receptor are necessary for induction...
IGF–1 and VEGF Receptor Signaling and Interaction in Human …
Using ribozymes specifically targeted against IGF–1 receptor (IGF–1R), VEGF receptor–1 (VEGFR–1) and VEGF receptor–2 (VEGFR–2), we investigated the relative contribution of …
Potent Inhibition of Angiogenesis by the IGF-1 Receptor …
Our data clearly indicate that signaling via the IGF-1R is essential for VEGF-stimulated processes that mimic angiogenesis in vitro, and suggest that IGF-1R signaling acts downstream of …
胰岛素样生长因子1受体 - 维基百科，自由的百科全书
胰岛素样生长因子1受体 （英語： insulin-like growth factor 1 receptor，IGF-1R）是人类 细胞 表面发现的 蛋白质，是激素 胰岛素样生长因子1 （IGF-1）的 细胞表面受体，属于 酪氨酸激酶 受 …
Inhibiting IGF-1R attenuates cell proliferation and VEGF ... - PubMed
The expression of EGFR, IGF-1R, AKT, extracellular regulated kinases 1 and 2 (ERK1/2), cleaved poly ADP ribose polymerase (PARP), cleaved caspase 3, and hypoxia-inducible factor (HIF) …
From Insight to Eyesight: Unveiling the Secrets of the Insulin-Like ...
2024年10月10日 · Interactions between IGF and IGFBPs can reduce free IGF levels, decreasing insulin-like growth factor receptor (IGF-1R) activation and inhibiting cellular response. IGF-2R, …
Insulin growth factor 1 like receptor (IGF-1R) - PMC
2016年10月6日 · In this study, we analyzed the immediate early molecular response of cetuximab on physical interactions between EGFR and Insulin growth factor 1 like receptor (IGF-1R) in …
IGF-1 induced vascular endothelial growth factor secretion in …
2006年4月14日 · VEGF expression is regulated by hypoxia and cytokines, including insulin-like growth factor-1 (IGF-1). In this report, we examined IGF-1 signaling and VEGF expression in …
β1-integrin controls IGF-1R internalisation and intracellular ...
2024年11月1日 · Cooperation between IGF and adhesion signalling in cancer and other proliferating or migrating cells is well documented ().In particular, engagement with integrins, …