In vivo tissue-tropism of adeno-associated viral vectors - PMC
In this review, a brief account of the historical perspective of the discovery of the first cellular receptor and co-receptor of the prototype adeno-associated virus serotype 2 (AAV2) will be presented.
In vivo tissue-tropism of adeno-associated viral vectors
In this review, a brief account of the historical perspective of the discovery of the first cellular receptor and co-receptor of the prototype adeno-associated virus serotype 2 (AAV2) will be presented. The Subsequent discovery of a number of AAV serotypes, and attempts to …
Receptors and tropisms of envelope viruses - PMC
Viral tropism can be determined by expression levels of viral receptors on target cells. The tropisms of viruses can be changed by modifying their receptor-binding specificity. The envelope lipid, phosphatidylserine, can mediate binding of virus.
Spatial transcriptomics for profiling the tropism of viral ... - Nature
2023年1月26日 · In this study, we developed an ultrasensitive, sequential fluorescence in situ hybridization (USeqFISH) method for spatial transcriptomic profiling of endogenous and viral RNA with a short...
Vector Tropism - SpringerLink
2023年2月7日 · To select a suitable viral vector, researchers should consider the gene size capacity of a vector, duration and timing of gene expression, type of viral genome nucleic acid (RNA vs. DNA), transcriptional regulation, tissue and cell tropism, immunogenicity, and toxicity of the vector in the targeted in vivo model.
Molecular Engineering of Virus Tropism - MDPI
2024年10月15日 · Engineering virus envelope or capsid proteins has provided compelling evidence for controlling virus tropism. Recent studies have also shown that modulating the expression of co-receptors, such as tetraspanins, can alter virus tropism or enhance viral vector transduction efficiency.
Cytokine determinants of viral tropism - Nature
2009年8月21日 · Viral tropism is the ability of a given virus to productively infect a particular cell (cellular tropism), tissue (tissue tropism) or host species (host tropism). Various host innate...
In vivo tissue-tropism of adeno-associated viral vectors
2016年12月1日 · Adeno-associated virus vector-mediated bcl-2 gene transfer into post-ischemic gerbil brain in vivo: prospects for gene therapy of ischemia-induced neuronal death
Viral Tropism: Mechanisms and Effects on Host Cells
2024年10月19日 · Tissue-Specific Tropism. Viruses demonstrate adaptability in their ability to preferentially infect certain tissues within a host, known as tissue-specific tropism. This selectivity is often dictated by an interplay of factors beyond receptor compatibility, including the local tissue environment and immune landscape.
Viral Genes and Tissue Tropism - SpringerLink
Recent studies with the mammalian reoviruses and their infection of newborn mice have identified the specific viral protein that determines tropism (the viral hemagglutinin) and have uncovered approaches to alter regions of the hemagglutinin selectively, thereby altering virulence and changing tropism [3].